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Neuronal Nicotinic Receptors

  • Book
  • © 2000

Overview

Editors:
  1. Francesco Clementi

    1. Università degli Studi di Milano Dipartimento di Farmacologia, Chemoterapia e Tossicologia Medica “Emilio Trabucchi”, Milano, Italy

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  2. Diego Fornasari

    1. Università degli Studi di Milano Dipartimento di Farmacologia, Chemoterapia e Tossicologia Medica “Emilio Trabucchi”, Milano, Italy

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  3. Cecilia Gotti

    1. Università degli Studi di Milano Dipartimento di Farmacologia, Chemoterapia e Tossicologia Medica “Emilio Trabucchi”, Milano, Italy

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 144)

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Table of contents (26 chapters)

  1. Front Matter

    Pages I-XXXI
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  3. Genes, Structure, and Distribution of Neuronal Nicotinic Receptors

    1. Front Matter

      Pages 31-31
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    2. Gene Structure and Transcriptional Regulation of the Neuronal Nicotinic Acetylcholine Receptors

      • J.-M. Matter, M. Ballivet
      Pages 33-55

    3. Transcriptional Regulation of Neuronal nAChR Subunit Genes

      • E. S. Deneris
      Pages 57-77

    4. Contributions of Studies of the Nicotinic Receptor from Muscle to Defining Structural and Functional Properties of Ligand-Gated Ion Channels

      • P. Taylor, H. Osaka, B. Molles, S. H. Keller, S. Malany
      Pages 79-100

    5. The Structures of Neuronal Nicotinic Receptors

      • J. Lindstrom
      Pages 101-162

    6. The Distribution of Neuronal Nicotinic Acetylcholine Receptors

      • P. B. Sargent
      Pages 163-192

    7. Presynaptic Neuronal Nicotinic Receptors: Pharmacology, Heterogeneity, and Cellular Mechanisms

      • S. Kaiser, L. Soliakov, S. Wonnacott
      Pages 193-211

    8. Neuronal Nicotinic Acetylcholine Receptors in Development and Aging

      • M. Zoli
      Pages 213-246

    9. Nicotinic Acetylcholine Receptors in Ganglionic Transmission

      • D. K. Berg, R. D. Shoop, K. T. Chang, J. Cuevas
      Pages 247-267

  4. Functional Properties

    1. Front Matter

      Pages 269-269
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    2. Neuronal Nicotinic Acetylcholine Receptors: From Biophysical Properties to Human Diseases

      • B. Buisson, F. Picard, D. Bertrand
      Pages 271-299

    3. The Functional Diversity of Nicotinic Receptors in the Nervous System: Perspectives on Receptor Subtypes and Receptor Specialization

      • M. M. Francis, R. L. Papke
      Pages 301-336

    4. Neuronal Nicotinic Receptors and Synaptic Transmission in the Mammalian Central Nervous System

      • E. X. Albuquerque, E. F. R. Pereira, M. Alkondon, H. M. Eisenberg, A. Maelicke
      Pages 337-358

    5. Properties of Heterologously and Lipid Bilayer Reconstituted Nicotinic Acetylcholine Receptors

      • C. Gotti, W. Hanke, F. Clementi
      Pages 359-378

    6. Comparison of Native and Recombinant Neuronal Nicotinic Receptors: Problems of Measurement and Expression

      • L. G. Sivilotti, D. Colquhoun, N. S. Millar
      Pages 379-416

  5. Pharmacological Properties

    1. Front Matter

      Pages 417-417
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Keywords

About this book

Neuronal nicotinic receptors are key molecules for signal transduction in a number of neuronal pathways. They are widely distributed in the brain and are known to be involved in cognitive tasks, including learning and memory, in smoking addiction and in several brain diseases, such as Alzheimer's and Parkinson's dementias, schizophrenia, and epilepsy. This book provides a comprehensive review of the field, starting with a historical perspective and dealing with the molecular structure of these receptors, their biophysical and pharmacological properties, their distribution in central and peripheral nervous systems, and their major involvement in brain functions. Particular emphasis is paid to drugs (both new and old) that are useful in the diagnosis and treatment of diseases involving neuronal nicotinic receptors. Finally, the relevance of these receptors in smoking addiction is carefully evaluated, together with future trends and the latest results.

Editors and Affiliations

  • Università degli Studi di Milano Dipartimento di Farmacologia, Chemoterapia e Tossicologia Medica “Emilio Trabucchi”, Milano, Italy

    Francesco Clementi, Diego Fornasari, Cecilia Gotti

Bibliographic Information

  • Book Title: Neuronal Nicotinic Receptors

  • Editors: Francesco Clementi, Diego Fornasari, Cecilia Gotti

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-57079-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heildelberg 2000

  • Hardcover ISBN: 978-3-540-66123-8Published: 16 June 2000

  • Softcover ISBN: 978-3-642-63027-9Published: 05 November 2012

  • eBook ISBN: 978-3-642-57079-7Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXXI, 821

  • Number of Illustrations: 83 b/w illustrations, 4 illustrations in colour

  • Topics: Pharmacology/Toxicology, Neurosciences, Molecular Medicine, Neurology, Psychiatry

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