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Neurotrophic Factors

  • Book
  • © 2014

Overview

Editors:
  1. Gary R. Lewin

    1. Department of Neuroscience, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Bruce D. Carter

    1. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • The relevance of neurotrophins in a variety of diseases ranging from inflammatory pain, to neurodegeneration and metabolic disease is comprehensively reviewed
  • The successful pharmacological avenues used for manipulating neurotrophin signalling in disease as well as future perspectives for their modulation is extensively reviewed
  • World renowned experts are revealing future perspectives for new therapies based on neurotrophin signalling and their downstream targets
  • Includes supplementary material: sn.pub/extras

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 220)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-viii
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  2. The Neurotrophin Family

    1. Front Matter

      Pages 1-1
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    2. NGF, BDNF, NT3, and NT4

      • M. Bothwell
      Pages 3-15

    3. Deciphering Proneurotrophin Actions

      • B. L. Hempstead
      Pages 17-32

    4. Spatiotemporal Intracellular Dynamics of Neurotrophin and Its Receptors. Implications for Neurotrophin Signaling and Neuronal Function

      • F. C. Bronfman, O. M. Lazo, C. Flores, C. A. Escudero
      Pages 33-65

    5. Neurotrophins: Transcription and Translation

      • A. E. West, P. Pruunsild, T. Timmusk
      Pages 67-100

  3. Neurotrophin Receptors

    1. Front Matter

      Pages 101-101
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    2. Trk Receptors

      • Katrin Deinhardt, Moses V. Chao
      Pages 103-119

    3. The Biological Functions and Signaling Mechanisms of the p75 Neurotrophin Receptor

      • B. R. Kraemer, S. O. Yoon, B. D. Carter
      Pages 121-164

    4. Sortilins in Neurotrophic Factor Signaling

      • S. Glerup, A. Nykjaer, C. B. Vaegter
      Pages 165-189

  4. The Biology of Neurotrophins

    1. Front Matter

      Pages 191-191
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    2. Neurotrophins in the Regulation of Cellular Survival and Death

      • Claire Ceni, Nicolas Unsain, Michele P. Zeinieh, Philip A. Barker
      Pages 193-221

    3. BDNF and Synaptic Plasticity, Cognitive Function, and Dysfunction

      • B. Lu, G. Nagappan, Y. Lu
      Pages 223-250

    4. Nerve Growth Factor and Nociception: From Experimental Embryology to New Analgesic Therapy

      • Gary R. Lewin, Stefan G. Lechner, Ewan St. John Smith
      Pages 251-282

    5. Neurotrophins and the Regulation of Energy Balance and Body Weight

      • M. Rios
      Pages 283-307

    6. The Biology of Neurotrophins: Cardiovascular Function

      • Costanza Emanueli, Marco Meloni, Wohaib Hasan, Beth A. Habecker
      Pages 309-328

    7. Neurotrophin Signalling and Transcription Programmes Interactions in the Development of Somatosensory Neurons

      • F. Marmigère, P. Carroll
      Pages 329-353

  5. Neurotrophins in Pathological Conditions

    1. Front Matter

      Pages 355-355
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    2. Huntington’s Disease

      • Chiara Zuccato, Elena Cattaneo
      Pages 357-409

    3. Motoneuron Disease

      • M. Sendtner
      Pages 411-441
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Keywords

About this book

This book provides critical reviews of the role of neurotrophins and their receptors in a wide variety of diseases including neurodegenerative diseases like Huntington’s syndrome, cognitive function, psychiatric disorders such as clinical depression, Rett syndrome, motoneurone disease, spinal cord injury, pain, metabolic disease and cardiovascular disease. It also contains contributions from leaders in the field dealing with the basic biology, transcriptional and post-translational regulation of the neurotrophins and their receptors. The present book will review all recent areas of progress in the study of neurotrophins and their biological roles.

Editors and Affiliations

  • Department of Neuroscience, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

    Gary R. Lewin

  • Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, USA

    Bruce D. Carter

Bibliographic Information

  • Book Title: Neurotrophic Factors

  • Editors: Gary R. Lewin, Bruce D. Carter

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-45106-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2014 2014

  • Hardcover ISBN: 978-3-642-45105-8Published: 08 April 2014

  • Softcover ISBN: 978-3-662-52089-5Published: 23 August 2016

  • eBook ISBN: 978-3-642-45106-5Published: 25 March 2014

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: VIII, 520

  • Number of Illustrations: 10 b/w illustrations, 27 illustrations in colour

  • Topics: Pharmacology/Toxicology, Molecular Medicine, Neurosciences

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