Voltage Gated Sodium Channels

1. Front Matter

   Pages i-viii

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2. Introduction to Sodium Channels

   • Colin H. Peters, Peter C. Ruben

   Pages 1-6

3. The Voltage Sensor Module in Sodium Channels

   • James R. Groome

   Pages 7-31

4. Slow Inactivation of Na+ Channels

   • Jonathan Silva

   Pages 33-49

5. The Role of Non-pore-Forming β Subunits in Physiology and Pathophysiology of Voltage-Gated Sodium Channels

   • Jeffrey D. Calhoun, Lori L. Isom

   Pages 51-89

6. Altered Sodium Channel Gating as Molecular Basis for Pain: Contribution of Activation, Inactivation, and Resurgent Currents

   • Angelika Lampert, Mirjam Eberhardt, Stephen G. Waxman

   Pages 91-110

7. Regulation/Modulation of Sensory Neuron Sodium Channels

   • Mohamed Chahine, Michael E. O’Leary

   Pages 111-135

8. The Role of Late I _Na in Development of Cardiac Arrhythmias

   • Charles Antzelevitch, Vladislav Nesterenko, John C. Shryock, Sridharan Rajamani, Yejia Song, Luiz Belardinelli

   Pages 137-168

9. Proton Modulation of Cardiac I _Na: A Potential Arrhythmogenic Trigger

   • David K. Jones, Peter C. Ruben

   Pages 169-181

10. Probing Gating Mechanisms of Sodium Channels Using Pore Blockers

    • Marcel P. Goldschen-Ohm, Baron Chanda

    Pages 183-201

11. Animal Toxins Influence Voltage-Gated Sodium Channel Function

    • John Gilchrist, Baldomero M. Olivera, Frank Bosmans

    Pages 203-229

12. Ubiquitylation of Voltage-Gated Sodium Channels

    • Cédric J. Laedermann, Isabelle Decosterd, Hugues Abriel

    Pages 231-250

13. Pharmacological Insights and Quirks of Bacterial Sodium Channels

    • Ben Corry, Sora Lee, Christopher A. Ahern

    Pages 251-267

14. Bacterial Sodium Channels: Models for Eukaryotic Sodium and Calcium Channels

    • Todd Scheuer

    Pages 269-291

15. Back Matter

    Pages 293-295

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A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

• channelopathies
• drug binding
• selectivity
• structure/function relationships
• toxins
• voltage-dependent gating
• Protein Structure

• Biomedical Physiology & Kinesiology, Simon Fraser University, Burnaby, Canada

  Peter C. Ruben

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