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Biomedical Sciences - Pharmacology & Toxicology | Arrestins - Pharmacology and Therapeutic Potential

Arrestins - Pharmacology and Therapeutic Potential

Gurevich, Vsevolod V. (Ed.)

2014, VIII, 447 p. 53 illus., 42 illus. in color.

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  • Discusses therapeutic potential of biased ligands of G protein-coupled receptors
  • Describes the molecular mechanisms and therapeutic implications of arrestin-mediated signaling
  • Discusses the potential of reengineered signaling proteins for gene therapy  

This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.

Content Level » Research

Keywords » G protein-coupled receptors - MAP kinases - apoptosis - arrestin - cell signaling - proliferation

Related subjects » Biochemistry & Biophysics - Cell Biology - Human Genetics - Pharmacology & Toxicology

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