Logo - springer
Slogan - springer

Biomedical Sciences - Pharmacology & Toxicology | Antibiotic Resistance

Antibiotic Resistance

Coates, Anthony R.M. (Ed.)

2012, VIII, 192 p.

Available Formats:
eBook
Information

Springer eBooks may be purchased by end-customers only and are sold without copy protection (DRM free). Instead, all eBooks include personalized watermarks. This means you can read the Springer eBooks across numerous devices such as Laptops, eReaders, and tablets.

You can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal.

After the purchase you can directly download the eBook file or read it online in our Springer eBook Reader. Furthermore your eBook will be stored in your MySpringer account. So you can always re-download your eBooks.

 
$329.00

(net) price for USA

ISBN 978-3-642-28951-4

digitally watermarked, no DRM

Included Format: PDF and EPUB

download immediately after purchase


learn more about Springer eBooks

add to marked items

Hardcover
Information

Hardcover version

You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.

Standard shipping is free of charge for individual customers.

 
$419.00

(net) price for USA

ISBN 978-3-642-28950-7

free shipping for individuals worldwide

usually dispatched within 3 to 5 business days


add to marked items

Softcover
Information

Softcover (also known as softback) version.

You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.

Standard shipping is free of charge for individual customers.

 
$419.00

(net) price for USA

ISBN 978-3-642-43249-1

free shipping for individuals worldwide

usually dispatched within 3 to 5 business days


add to marked items

  • This book provides views about antibiotic resistance from world experts in the field
  • The book has constructive ways in which to combat resistance,such as combinations of antibiotics, and targeting non-multiplying bacteria
  • It provides an outline of the challenges of the future, namely the need for a rebirth of the golden age of antibiotics in the mid-20th Century when 20 new classes of antibiotics reached the market
This book describes antibiotic resistance amongst pathogenic bacteria. It starts with an overview of the erosion of the efficacy of antibiotics by resistance and the decrease in the rate of replacement of redundant compounds. The origins of antibiotic resistance are then described. It is proposed that there is a large bacterial resistome which is a collection of all resistance genes and their precursors in both pathogenic and non-pathogenic bacteria. Ongoing resistance surveillance programs are also discussed, together with the perspective of a clinical microbiologist. The book then turns to specific themes such as the most serious area of resistance in pathogens, namely in Gram-negative organisms. The role of combinations of antibiotics in combating resistance emergence is discussed, particularly in the tuberculosis field, and then the importance of non-multiplying and persistent bacteria which are phenotypically resistant to antibiotics and prolong the duration of therapy of antibiotics which leads to poor compliance and resistance emergence. The role of anti-microbial compounds in textiles is covered, with its potential to exacerbate the spread of resistance. Then, efflux pumps are discussed. The final chapter describes the compounds which are in late stage clinical development, illustrating the paucity of the antibiotic pipeline, especially for Gram-negative bacteria.

Content Level » Research

Keywords » Antibiotic resistance - Clinical trials - Gram-negative bacteria - Non-multiplying - Origins

Related subjects » Medical Microbiology - Pharmacology & Toxicology

Table of contents 

Preface.- Introduction to antibiotic resistance.- Origins of antibiotic resistance.- Surveillance Programs and Antibiotic Resistance: Worldwide and Regional Monitoring of Antibiotic Resistance Trends.- Current and future challenges in the development of antimicrobial agents.- Resistance in Gram-negative bacteria.- Non-multiplying bacteria are profoundly tolerant to antibiotics.- Prevention of drug resistance by multidrug treatment of tuberculosis.- Persister cells–molecular mechanisms related to antibiotic tolerance.- Antimicrobial textiles.- Efflux – how bacteria use pumps to control their micro-environment.- Antibiotics in Phase II and III clinical trials.

Popular Content within this publication 

 

Articles

Read this Book on Springerlink

Services for this book

New Book Alert

Get alerted on new Springer publications in the subject area of Pharmacology / Toxicology.