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Biomedical Sciences - Pharmacology & Toxicology | Sparking Signals - Kinases as Molecular Signaltransducers and Pharmacological Drug Targets in

Sparking Signals

Kinases as Molecular Signaltransducers and Pharmacological Drug Targets in Inflammation

Baier, G., Schraven, B., Zügel, U., von Bonin, A. (Eds.)

2008, XIV, 187 p.

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  • Internationally well known experts presented their most recent findings on the fast developing kinase field
  • Outstanding interest for basic researchers and the pharmaceutical industry

Protein phosphorylation is an essential post-translational modification that modulates cell–cell communication. Substrate phosphorylation by protein kinases controls intracellular signal transduction pathways that mediate cell proliferation, migration, differentiation, and metabolism. The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent progress in understanding the molecular regulation of kinases has led to the development of new therapeutics based on the inhibition of kinase activity. Inhibitors that target protein kinases have proven efficacious in clinical settings and their continued development is the current focus of many drug discovery groups.

Content Level » Professional/practitioner

Keywords » Cellular Signalling - Drug Finding - Immune-modulation - Kinase Inhibitors - Proteomics - Translation - metabolism

Related subjects » Biochemistry & Biophysics - Immunology - Pharmacology & Toxicology

Table of contents 

Proteomics-Based Strategies in Kinase Drug Discovery.- PKC Isotype Functions in T Lymphocytes.- Migration, Cell–Cell Interaction and Adhesion in the Immune System.- Molecular Mechanisms that Control Leukocyte Extravasation Through Endothelial Cell Contacts.- Fragment-Based Drug Discovery Using Rational Design.- Systems Biology of T Cell Activation.- Solving the IRAK-4 Enigma: Application of Kinase-Dead Knock-In Mice.- Sensing, Presenting, and Regulating PAMPS.- The Role of Diacylglycerol Kinases in T Cell Anergy.

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