Mammalian Transient Receptor Potential (TRP) Cation Channels

1. Front Matter

   Pages i-xi

   PDF

2. TRPs as Special Cell Sensors

   1. TRP Channels and Thermosensation

      • Thomas Voets

      Pages 729-741

   2. TRPs in Mechanosensing and Volume Regulation

      • Tim D. Plant

      Pages 743-766

   3. TRPs as Chemosensors (ROS, RNS, RCS, Gasotransmitters)

      • Shunichi Shimizu, Nobuaki Takahashi, Yasuo Mori

      Pages 767-794

   4. Photosensitive TRPs

      • Roger C. Hardie

      Pages 795-826

   5. TRPs in Taste and Chemesthesis

      • Stephen D. Roper

      Pages 827-871

   6. TRPs and Pain

      • Jane E. Sexton, Jeffrey Vernon, John N. Wood

      Pages 873-897

   7. TRPs in Hearing

      • Damiano Zanini, Martin C. Göpfert

      Pages 899-916

   8. TRPs in Olfaction

      • Frank Zufall

      Pages 917-933

3. General Topics

   1. Evolutionarily Conserved, Multitasking TRP Channels: Lessons from Worms and Flies

      • Kartik Venkatachalam, Junjie Luo, Craig Montell

      Pages 937-962

   2. Structural Biology of TRP Channels

      • Ute A. Hellmich, Rachelle Gaudet

      Pages 963-990

   3. High-Resolution Views of TRPV1 and Their Implications for the TRP Channel Superfamily

      • Ute A. Hellmich, Rachelle Gaudet

      Pages 991-1004

   4. Physiological Functions and Regulation of TRPC Channels

      • Hwei Ling Ong, Lorena B. de Souza, Kwong Tai Cheng, Indu S. Ambudkar

      Pages 1005-1034

   5. The TRPCs–STIM1–Orai Interaction

      • Seok Choi, Jozsef Maleth, Archana Jha, Kyu Pil Lee, Min Seuk Kim, Insuk So et al.

      Pages 1035-1054

   6. The TRPC Family of TRP Channels: Roles Inferred (Mostly) from Knockout Mice and Relationship to ORAI Proteins

      • Yanhong Liao, Joel Abramowitz, Lutz Birnbaumer

      Pages 1055-1075

   7. TRPs: Modulation by Drug-Like Compounds

      • Michael Schaefer

      Pages 1077-1106

   8. TRP Channels in Reproductive (Neuro)Endocrinology

      • Trese Leinders-Zufall, Ulrich Boehm

      Pages 1107-1118

   9. Modulation of TRP Ion Channels by Venomous Toxins

      • Jan Siemens, Christina Hanack

      Pages 1119-1142

   10. Phosphoinositide Regulation of TRP Channels

       • Tibor Rohacs

       Pages 1143-1176

   11. TRP Modulation by Natural Compounds

       • Flavia Carla Meotti, Edinéia Lemos de Andrade, João B. Calixto

       Pages 1177-1238

​In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Receptor Potential (TRP) Channels provides valuable information for readers with different expectations and backgrounds, for those who are approaching this field of research as well as for those wanting to make a trip to TRPs.

• Pain perception
• TRP channels
• TRP pharmacology
• Temperature sensors

• Laboratory Ion Channel Research, Campus Gasthuisberg, KU Leuven Department, Cell Mol Medicin, Leuven, Belgium

  Bernd Nilius

• Pharmakologie und Toxikologie, Universität des Saarlandes, Institut für Experimentelle u. Klinische, Homburg, Germany

  Veit Flockerzi

Policies and ethics