Editors:
Summarizes preclinical and clinical data
A valuable source of information for scientists and clinicians
Contemporary monograph on the pharmacotherapy of COPD
Includes supplementary material: sn.pub/extras
Part of the book series: Milestones in Drug Therapy (MDT)
Buy it now
Buying options
Tax calculation will be finalised at checkout
Other ways to access
This is a preview of subscription content, log in via an institution to check for access.
Table of contents (9 chapters)
-
Front Matter
About this book
Chronic obstructive pulmonary disease (COPD) is a multi-component condition that results in increasingly limited airflow, usually associated with an abnormal inflammatory response of the lung. It constitutes a major public health burden worldwide, while only very few effective therapies are available.
This book provides a comprehensive overview of the development of Onbrez Breezhaler, a newly approved once-daily inhaled β2 agonist for the treatment of COPD. It reviews the current pharmacotherapy for COPD and discusses topics such as the chemical design and the pre-clinical pharmacology of the molecule, the early clinical development, the INHANCE study (which provides a successful example of the use of an adaptive design in the confirmatory setting) and the Phase III clinical efficacy study, as well as the history and performance of the Breezhaler device. Finally, a list of emerging targets is included that could well offer future treatment options for COPD.
Editors and Affiliations
-
Respiratory Diseases Area, Novartis Institutes for BioMedical Reseach, Basel, Switzerland
Alexandre Trifilieff
Bibliographic Information
Book Title: Indacaterol
Book Subtitle: The First Once-daily Long-acting Beta2 Agonist for COPD
Editors: Alexandre Trifilieff
Series Title: Milestones in Drug Therapy
DOI: https://doi.org/10.1007/978-3-0348-0709-8
Publisher: Springer Basel
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Basel 2014
Hardcover ISBN: 978-3-0348-0708-1Published: 27 November 2013
eBook ISBN: 978-3-0348-0709-8Published: 19 November 2013
Series ISSN: 2296-6056
Series E-ISSN: 2296-6064
Edition Number: 1
Number of Pages: VII, 146
Number of Illustrations: 20 b/w illustrations, 21 illustrations in colour
Topics: Pharmacology/Toxicology, Pneumology/Respiratory System