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Twenty Years of G-CSF

Clinical and Nonclinical Discoveries

  • Book
  • © 2012

Overview

Editors:
  1. Graham Molineux

    1. Amgen Inc., Thousand Oaks, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. MaryAnn Foote

    1. MA Foote Associates, Westlake Village, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Tara Arvedson

    1. Amgen, Inc., Thousand Oaks, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Many of the authors are the original investigators of recombinant human G-CSF
  • Key researchers provide their outlook for the next 20 years
  • Describes oncological and non-oncological applications
  • Includes supplementary material: sn.pub/extras

Part of the book series: Milestones in Drug Therapy (MDT)

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Table of contents (25 chapters)

  1. Front Matter

    Pages i-xxii
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  2. Basic Science

    1. Front Matter

      Pages 1-1
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    2. Hematopoiesis in 2010

      • George Morstyn
      Pages 3-13

    3. Discovery of G-CSF and Early Clinical Studies

      • Karl Welte
      Pages 15-24

    4. Mouse Models of G-CSF Signaling in Hematopoiesis

      • Daniel C Link
      Pages 25-40

    5. The Clinical Pharmacology of Filgrastim and Pegfilgrastim

      • Lorin K. Roskos
      Pages 41-60

    6. Structural Biology of G-CSF and Its Receptor

      • Tara L. Arvedson, Mike J. Giffin
      Pages 61-82

    7. G-CSF Receptor Structure, Function, and Intracellular Signal Transduction

      • Hoainam T. Nguyen-Jackson, Huiyuan Zhang, Stephanie S. Watowich
      Pages 83-105

  3. Use of rHuG-CSF in the Oncology Setting

    1. Front Matter

      Pages 107-107
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    2. Practice Guidelines for the Use of rHuG-CSF in an Oncology Setting

      • Santosh Saraf, Howard Ozer
      Pages 109-149

    3. Use of r-metHuG-CSF to Enable Chemotherapy Delivery for Solid Tumors

      • Tara L. Arvedson, Graham Molineux
      Pages 151-168

    4. Use of rHuG-CSF for the Treatment of Myeloid Leukemia and in Targeting Leukemia Stem Cells

      • Fumihiko Ishikawa
      Pages 169-182

    5. Use of rHuG-CSF in Myelodysplastic Syndromes

      • Mojtaba Akhtari, Lori Maness
      Pages 183-193

    6. The Role of Hematopoietic Growth Factors in Aplastic Anemia: An Evidence-Based Perspective

      • Pia Raanani, Ronit Gurion, Anat Gafter-Gvili, Isaac Ben-Bassat, Ofer Shpilberg
      Pages 195-210

    7. Using rHuG-CSF in Multiple Myeloma: Consolidated Data, Evolutions, and New Concepts

      • Pellegrino Musto
      Pages 211-223

    8. Use of rHuG-CSF in New Chemotherapy Strategies

      • William Renwick
      Pages 225-247

    9. rHuG-CSF in Peripheral Blood Progenitor Cell Transplantation

      • Ashanka Beligaswatte, Ian Lewis, Luen Bik To
      Pages 249-275

  4. Use of rHuG-CSF in Non-Oncology Setting

    1. Front Matter

      Pages 277-277
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    2. rHuG-CSF for the Treatment of Severe Chronic Neutropenia

      • David C. Dale, Audrey Anna Bolyard
      Pages 279-291

    3. Investigational Studies of rHuG-CSF to Promote the Regeneration of Nonhematopoietic Tissues

      • Stephen J. Szilvassy
      Pages 293-317
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Keywords

About this book

Granulocyte colony-stimulating factor (G-CSF or GCSF) is a secreted glycoprotein that stimulates the proliferation and differentiation of granulocyte precursor cells, and induces mobilization of peripheral blood progenitor cells from the bone marrow. Development of recombinant human G-CSF has had a profound impact on the treatment of many diseases, including severe chronic neutropenia and cancer, and has enabled peripheral stem cell transplantation to supplant bone marrow transplantation in the autologous setting.

This Milestones in Drug Therapy volume describes the experience of the last 20 years of treatment with recombinant human G-CSF, including the basic science, the use of recombinant human G-CSF in both the oncology and nononcology settings, and the safety and economics of its use. Many of the authors were the original investigators of recombinant human G-CSF and other authors are key researchers who provide their outlook for the next 20 years for use of and research with recombinant human G-CSF.

Editors and Affiliations

  • Amgen Inc., Thousand Oaks, USA

    Graham Molineux

  • MA Foote Associates, Westlake Village, USA

    MaryAnn Foote

  • Amgen, Inc., Thousand Oaks, USA

    Tara Arvedson

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