Treatment and Prevention of Malaria

Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions.  

Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. There is particular emphasis on artemisinins and related peroxides, as these drugs have now become the frontline treatment for malaria. Next generation antimalarials, molecular markers for detecting resistance, the importance of diagnostics and disease prevention are also covered in detail.

• Antimalarial drugs
• Artemisinin
• Chemoprophylaxis
• Combination therapy
• Disease control
• Drug resistance
• Malaria
• Plasmodium
• infectious diseases
• antibacterial drug resistance

From the reviews:

“Staines and Krishna successfully captures the essence of what we know about antimalarials at the beginning of the second decade of the 21st century. … the book is a welcome and highly valuable documentation on where we stand and offers valuable food for thought in the search for the way forward.” (Martin P. Grobusch, Trends in Parasitology, September, 2012)

• Centre for Infection, Div. Cellular & Molecular Medicine, St. George's University of London, London, United Kingdom

  Henry M. Staines

• Medical School, Dept. Infectious Diseases, St. George´s Hospital, London, United Kingdom

  Sanjeev Krishna

Policies and ethics