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Biomedical Sciences - Pharmacology & Toxicology | Enzyme Kinetics in Drug Metabolism - Fundamentals and Applications

Enzyme Kinetics in Drug Metabolism

Fundamentals and Applications

Series: Methods in Molecular Biology, Vol. 1113

Nagar, Swati, Argikar, Upendra, Tweedie, Donald (Eds.)

2014, XVIII, 538 p. 134 illus., 36 illus. in color.

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  • Includes clear explanations of fundamentals for correct application
  • Contains key notes, experiences and implementation advice from the experts
  • Covers relevant and current topics including Drug Metabolizing Enzymes and Transporters

Drug metabolism and transport are very important facets within the discipline of pharmaceutical sciences, with  enzyme kinetic concepts utilized regularly in characterizing and modeling the disposition and elimination of drugs. Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications focuses on very practical aspects of applying kinetic principles to drug metabolizing enzymes and transporters. Divided into five convenient sections, topics include the fundamental principles of enzyme kinetics, the kinetics of oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches for both drug metabolizing enzymes and transporters including novel systems biology approaches, understanding of variability both experimental and interindividual (pharmacogenomic), and case studies that provide real life examples of applying these principles. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics especially suitable for the novice, in some cases step-by-step, readily reproducible protocols, and insights to help with troubleshooting and avoiding known pitfalls with extensive cross referencing to assist in learning.

 

Authoritative and easily accessible, Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications serves as a very practical teaching tool for novice, non-mathematically trained scientists interested in these fundamental concepts and as an aid for their supervisors in teaching these principles.   

Content Level » Professional/practitioner

Keywords » drug metabolism - drug transporters - enzyme kinetic models - enzyme kinetics - kinetic analysis - transporter kinetics

Related subjects » Pharmacology & Toxicology

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