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Biomedical Sciences - Pharmacology & Toxicology | Metabolomics Tools for Natural Product Discovery - Methods and Protocols

Metabolomics Tools for Natural Product Discovery

Methods and Protocols

Series: Methods in Molecular Biology, Vol. 1055

Roessner, Ute, Dias, Daniel Anthony (Eds.)

2013, X, 311 p. 83 illus., 33 illus. in color.

A product of Humana Press
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  • About this book

  • Includes cutting-edge methos and protocols
  • Provides step-by-step detail essential to reproducible results
  • Contains key notes and implementation advice from the experts

Classical natural product chemistry is transitioning to modern day metabolomics as a result of the advent of comprehensive analytical platforms and sensitive analytical instrumentation. Therefore, it is worthwhile to summarize recent developments with current analytical platforms and highlight how metabolomics is being integrated into this classical field to dereplicate and profile natural product extracts. Metabolomics Tools for Natural Product Discoveries: Methods and Protocols aims to unite diverse and recently developed methodologies and protocols in order to identify bioactive secondary metabolites for the purpose of drug discovery. Some topics covered in this volume include applications for the extraction of selected natural products from less common sources such as bryophytes and hard corals, various biological assays, comprehensive applications and strategies for GC-MS, LC-MS, and NMR, as well as protocols and strategies for the structure elucidation of isolated natural products.  Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

 

Authoritative and easily accessible Metabolomics Tools for Natural Product Discoveries: Methods and Protocols seeks to serve both professionals and research students with its well-honed methodologies for natural product isolation, biomarker discovery, dereplication, biological assays, and comprehensive metabolomic platforms available for high-throughput analyses.

Content Level » Professional/practitioner

Keywords » NMR spectroscopy - lipidomics - mass spectrometry - metabolites - metabolomics

Related subjects » Analytical Chemistry - Pharmacology & Toxicology

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Distribution rights for India: Mehul Book Sales, Mumbai, India

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