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Biomedical Sciences - Pharmacology & Toxicology | Antibody-Drug Conjugates

Antibody-Drug Conjugates

Series: Methods in Molecular Biology, Vol. 1045

Ducry, Laurent (Ed.)

2013, X, 317 p. 96 illus., 42 illus. in color.

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  • Supports the development of innovative cancer treatments through ADC techniques
  • Provides step-by-step methodologies that are readily reproducible
  • Features expert tips and key implementation advice to ensure successful results

Antibody-drug conjugates (ADCs) represent a promising therapeutic approach for cancer patients by combining the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic potency of chemotherapeutic drugs.  In Antibody-Drug Conjugates, expert researchers provide detailed protocols for many of the key ADC techniques necessary for working in the field. These chapters and methodologies are aimed at the key tasks necessary to identify a suitable target, properly design the mAb, the linker and the payload, as well as to conjugate them in a reproducible and scalable fashion.  Written in the highly successful Methods in Molecular Biology™ format, these detailed chapters include the kind of practical implementation advice that guarantees quality results.

 

Authoritative and timely, Antibody-Drug Conjugates aims to further drive ADC development and thus help toward improving cancer treatments of the future.

Content Level » Professional/practitioner

Keywords » ADCs - Anti-cancer biotherapeutics - Antigen-targeting - Cancer treatment - Immunoconjugates - Monoclonal antibodies - Tumor therapies

Related subjects » Oncology & Hematology - Pharmacology & Toxicology

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