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  • Book
  • © 2009

The Cannabinoid Receptors

  • Offers a comprehensive look at cannabinoid structure activity relationships for all structural classes of cannabinoid agonists, including endogenous cannabinoids as well as cannabinoid antagonists/inverse agonists
  • Provides a thorough overview of the cannabinoid receptor field including the genetics and evolution of the cannabinoid system, as well as the molecular biology and structure/function of the cannabinoid receptors
  • Discusses the many therapeutic opportunities provided by the endocannabinoid system, including treatments for metabolic syndrome and immune system disorders

Part of the book series: The Receptors (REC)

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Hardcover Book USD 169.99
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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xiv
  2. Cannabinoid Receptor Ligands and Structure-Activity Relationships

    1. Front Matter

      Pages 1-1
    2. Endocannabinoids and Their Synthetic Analogs

      • V. Kiran Vemuri, Alexandros Makriyannis
      Pages 21-48
    3. Structure–Activity Relationships and Conformational Freedom of CB1 Receptor Antagonists and Inverse Agonists

      • Yanan Zhang, Herbert H. Seltzman, Marcus Brackeen, Brian F. Thomas
      Pages 95-119
  3. Cannabinoid Receptor Biology

    1. Front Matter

      Pages 121-121
    2. Cannabinoid Receptor Genetics and Evolution

      • Maurice R. Elphick, Michaela Egertová
      Pages 123-149
  4. Cannabinoid Receptor Molecular Pharmacology

    1. Front Matter

      Pages 151-151
    2. Cannabinoid Receptor Signal Transduction Pathways

      • Emma Scotter, Scott Graham, Michelle Glass
      Pages 153-171
    3. Cannabinoid Agonist and Inverse Agonist Regulation of G Protein Coupling

      • Allyn C. Howlett, Lea W. Padgett, Joong-Youn Shim
      Pages 173-202
  5. The Endocannabinoid System

    1. Front Matter

      Pages 280-280
    2. Endocannabinoids as Modulators of Synaptic Signaling

      • Sachin Patel, Cecilia J. Hillard
      Pages 281-308
  6. Cannabinoid Receptor Pharmacology

    1. Front Matter

      Pages 328-328
    2. Therapeutic Applications for Agents that Act at CB1 and CB2 Receptors

      • Roger G. Pertwee, Adèle Thomas
      Pages 361-392
  7. Back Matter

    Pages 393-396

About this book

As research has progressed, the cannabinoid CB 1 and CB 2 receptors have expanded significantly in importance within the neuroscience mainstream. In The Cannabinoid Receptors, leading experts introduce newcomers to the cannabinoid field with chapters covering cannabinoid ligand synthesis and structure activity relationships, the molecular pharmacology of the cannabinoid receptors and the endocannabinoid system, and ultimately, the whole animal pharmacology and therapeutic applications for cannabinoid drugs. Adding to those key topics, the book also examines the current direction of the field with chapters on new putative cannabinoid receptors and challenges for future research. As a part of The Receptors ™ series, this volume highlights its receptor with the most thorough, focused and essential information available.

Comprehensive and cutting-edge, The Cannabinoid Receptors serves as an ideal guidebook to what continues to be a fascinating and vital field.

Reviews

From the reviews:

"The Cannabinoid Receptors arrives as the 18 member of The Receptors series and offers the reader a sophisticated overview of the structure–activity relationship advances realized in the design of cannabinoid (CB) based drugs. The book presents CB receptors in five parts … . The chapters are thoroughly referenced, including the latest primary literature, and the index serves well. … The intended audience includes industry/academic medicinal chemists and pharmacologists who are new to the CB field." (Kennerly S. Patrick, Journal of Medicinal Chemistry, September, 2009)

“This book is great if you want a lot of information about the cannabinoid receptors in one place; from evolution to molecular biology and medicinal chemistry, it is all here. … This is a nicely written piece presenting molecular modelling analyses of the cannabinoid ligands. … This book is intended for newcomers to the cannabinoid field … . it is a good book to have.” (David Selwood, ChemMedChem, Issue 4, 2009)

Editors and Affiliations

  • University of North Carolina, Greensboro, USA

    Patricia H. Reggio

Bibliographic Information

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access