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Offers a comprehensive look at cannabinoid structure activity relationships for all structural classes of cannabinoid agonists, including endogenous cannabinoids as well as cannabinoid antagonists/inverse agonists
Provides a thorough overview of the cannabinoid receptor field including the genetics and evolution of the cannabinoid system, as well as the molecular biology and structure/function of the cannabinoid receptors
Discusses the many therapeutic opportunities provided by the endocannabinoid system, including treatments for metabolic syndrome and immune system disorders
As research has progressed, the cannabinoid CB 1 and CB 2 receptors have expanded significantly in importance within the neuroscience mainstream. In The Cannabinoid Receptors, leading experts introduce newcomers to the cannabinoid field with chapters covering cannabinoid ligand synthesis and structure activity relationships, the molecular pharmacology of the cannabinoid receptors and the endocannabinoid system, and ultimately, the whole animal pharmacology and therapeutic applications for cannabinoid drugs. Adding to those key topics, the book also examines the current direction of the field with chapters on new putative cannabinoid receptors and challenges for future research. As a part of The Receptors ™ series, this volume highlights its receptor with the most thorough, focused and essential information available.
Comprehensive and cutting-edge, The Cannabinoid Receptors serves as an ideal guidebook to what continues to be a fascinating and vital field.
I. Cannabinoid Receptor Ligands and Structure Activity Relationships
Chapter 1. Structure Activity Relationships (SAR) of Classical Cannabinoids
Raj K. Razdan
Chapter 2. Endocannabinoids and Their Synthetic Analogs
V. Kiran Vemuri and Alexandros Makriyannis
Chapter 3. Cannabimimetic Indoles, Pyrroles and Indenes: Structure-Activity Relationships and Receptor Interactions
John W. Huffman
Chapter 4. Structure-Activity Relationships and Conformational Freedom of CB1 Receptor Antagonists and Inverse Agonists
Yanan Zhang, Herbert H. Seltzman, Marcus Brackeen and Brian F. Thomas
II. Cannabinoid Receptor Biology
Chapter 5. Cannabinoid Receptor Genetics and Evolution
Maurice R. Elphick and Michaela Egertová
III. Cannabinoid Receptor Molecular Pharmacology
Chapter 6. Cannabinoid Receptor Signal Transduction Pathways
Emma Scotter, Scott Graham and Michelle Glass
Chapter 7. Cannabinoid Agonist and Inverse Agonist Regulation of G-Protein Coupling
Allyn C. Howlett, Lea W. Padgett and Joong-Youn Shim
Chapter 8. Molecular Biology of Cannabinoid Receptors: Mutational Analyses of the CB receptors
Mary E. Abood
Chapter 9. Models of Cannabinoid Inverse Agonism, Neutral Antagonism and Agonism: Tools for RationalDrug Design
Dow P. Hurst and Patricia H. Reggio
IV. The Endocannabinoid System
Chapter 10. Endocannabinoids as Modulators of Synaptic Signaling
Sachin Patel and Cecilia J. Hillard
Chapter 11. New Insights into the Endocannabinoid System by using Cannabinoid Receptor Knockout Mice
Meliha Karsak, Itai Bab and Andreas Zimmer
V. Cannabinoid Receptor Pharmacology
Chapter 12. Preclinical Pharmacological and Brain Bioassay Systems for CB1 Cannabinoid Receptors
Jenny L. Wiley and Billy R. Martin
Chapter 13. Therapeutic Applications for Agents that Act at CB1 and CB2 Receptors
Roger G. Pertwee and Adèle Thomas