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The Serotonin Receptors

From Molecular Pharmacology to Human Therapeutics

  • Book
  • © 2006

Overview

Editors:
  1. Bryan L. Roth

    1. Department of Biochemistry, Case Western Reserve University-School of Medicine, Cleveland

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Part of the book series: The Receptors (REC)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xvii
    Download chapter PDF

  2. Molecular Biology and Genomic Organization of G Protein-Coupled Serotonin Receptors

    • Wesley K. Kroeze, Bryan L. Roth
    Pages 1-38

  3. Structure and Function Reveal Insights in the Pharmacology of 5-HT Receptor Subtypes

    • Richard B. Westkaemper, Bryan L. Roth
    Pages 39-58

  4. Polymorphic and Posttranscriptional Modifications of 5-HT Receptor Structure

    • Marilyn A. Davies, Chiao-ying Chang, Bryan L. Roth
    Pages 59-90

  5. Strategies for the Development of Selective Serotonergic Agents

    • Richard A. Glennon
    Pages 91-142

  6. 5-HT Receptor Signal Transduction Pathways

    • Justin H. Turner, Andrew K. Gelasco, Henry B. Ayiku, Sonya D. Coaxum, John M. Arthur, Maria N. Garnovskaya
    Pages 143-206

  7. Agonist-Directed Trafficking of 5-HT Receptor-Mediated Signal Transduction

    • Kelly A. Berg, William P. Clarke
    Pages 207-235

  8. Identification of 5-HT2 and 5-HT4 Receptor-Interacting Proteins

    • Joël Bockaert, Carine Bécamel, Lara Joubert, Sophie Gavarini, Aline Dumuis, Philippe Marin
    Pages 237-255

  9. 5-HT Receptor-Associated Proteins (FRAPs)

    • Zongqi Xia, Douglas J. Sheffler, Bryan L. Roth
    Pages 257-276

  10. Cellular and Subcellular Localization of Serotonin Receptors in the Central Nervous System

    • Laurent Descarries, Virginia Cornea-Hébert, Mustapha Riad
    Pages 277-317

  11. Chemical Neuroanatomy of 5-HT Receptor Subtypes in the Mammalian Brain

    • Guadalupe Mengod, M. Teresa Vilaró, Roser Cortés, Juan F. López-Giménez, Andreu Raurich, José M. Palacios
    Pages 319-364

  12. Modulation of the Neuronal Activity and Neurotransmitter Release by 5-HT1A and 5-HT1B/1D Receptors

    • Pau Celada, Albert Adell, Francesc Artigas
    Pages 365-401

  13. Electrophysiology of 5-HT2A Receptors and Relevance for Hallucinogen and Atypical Antipsychotic Drug Actions

    • Evelyn K. Lambe, George K. Aghajanian
    Pages 403-417

  14. The Emergence of 5-HT2B Receptors as Targets to Avoid in Designing and Refining Pharmaceuticals

    • Vincent Setola, Bryan L. Roth
    Pages 419-438

  15. The 5-HT3 Receptor

    • Andrew J. Thompson, Li Zhang, Sarah C. R. Lummis
    Pages 439-457

  16. 5-HT3 and 5-HT4 Receptors as Targets for Drug Discovery for Dementia

    • Frank Lezoualc’h, Magali Berthouze
    Pages 459-479

  17. Electrophysiological Properties of Gαs-Coupled 5-HT Receptors (5-HT4, 5-HT6, 5-HT7)

    • Rodrigo Andrade
    Pages 481-494

  18. 5-HT6 Receptors as Targets for the Treatment of Cognitive Deficits in Schizophrenia

    • Rudy Schreiber, Andrew Sleight, Marie Woolley
    Pages 495-515

  19. 5-HT7 Receptors as Favorable Pharmacological Targets for Drug Discovery

    • Peter B. Hedlund, J. Gregor Sutcliffe
    Pages 517-535

  20. Serotonin System Gene Knockouts

    • Miles Berger, Laurence H. Tecott
    Pages 537-575
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Keywords

About this book

A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

Reviews

From the reviews:

"This is a compilation of reviews regarding various aspects of serotonin receptor structure and function. … As a set of reviews, the book can be read by a broad scientific audience. Material of interest to senior scientists and research fellows is present. … Investigators wishing an up-to-date review of this field will find this book valuable. Those with selected interest, whether evolutionary or structural, will also find useful material. … is a good, comprehensive set of reviews. … overall, it is a valuable book." (Eugene A Davidson, Doody’s Review Service, February, 2007)

Editors and Affiliations

  • Department of Biochemistry, Case Western Reserve University-School of Medicine, Cleveland

    Bryan L. Roth

Bibliographic Information

  • Book Title: The Serotonin Receptors

  • Book Subtitle: From Molecular Pharmacology to Human Therapeutics

  • Editors: Bryan L. Roth

  • Series Title: The Receptors

  • DOI: https://doi.org/10.1007/978-1-59745-080-5

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2006

  • Hardcover ISBN: 978-1-58829-568-2Published: 01 June 2006

  • Softcover ISBN: 978-1-61737-647-4Published: 09 November 2010

  • eBook ISBN: 978-1-59745-080-5Published: 17 August 2008

  • Series ISSN: 1048-6909

  • Series E-ISSN: 2524-6488

  • Edition Number: 1

  • Number of Pages: XVIII, 618

  • Number of Illustrations: 77 b/w illustrations, 5 illustrations in colour

  • Topics: Pharmacy

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