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Biomedical Sciences - Pharmacology & Toxicology | Discovering and Developing Molecules with Optimal Drug-Like Properties

Discovering and Developing Molecules with Optimal Drug-Like Properties

Templeton, A.C., Byrn, S.R., Haskell, R.J., Prisinzano, Th.E. (Eds.)

2015, XI, 511 p. 161 illus., 130 illus. in color.

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  • Addresses the challenge to select better molecules for drug development more efficiently
  • Discusses how to expand the chemical space within which a pharmacological benefit can be found
  • Examines the real value of discovery-oriented pharmaceutical sciences​

This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties. It is a valuable source to access current best practices as well as new research techniques and strategies. Written by leading scientists in their fields, the text consists of fourteen chapters with an underlying theme of early collaborative opportunities between pharmaceutical and discovery sciences. The book explores the practical realities of performing physical pharmaceutical and biopharmaceutical research in the context of drug discovery with short timelines and low compound availability. Chapters cover strategies and tactics to enable discovery as well as predictive approaches to establish, understand and communicate risks in early development. It also examines the detection, characterization and assessment of risks on the solid state properties of advanced discovery and early development candidates, highlighting the link between solid state properties and critical development parameters such as solubility and stability. Final chapters center on techniques to improve molecular solubilization and prevent precipitation, with particularly emphasis on linking physiochemical properties of molecules to formulation selection in preclinical and clinical settings.

Content Level » Research

Keywords » drug delivery - in silico - modeling - physicochemical

Related subjects » Pharmacology & Toxicology

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