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  • © 2014

Pharmacogenomics in Drug Discovery and Development

Editors:

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 1175)

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Table of contents (19 protocols)

  1. Front Matter

    Pages i-xiii
  2. Systems and “Omics” Studies in Pharmacogenomics

    1. Front Matter

      Pages 1-1
    2. Diagnostic Procedures for Paraffin-Embedded Tissues Analysis in Pharmacogenomic Studies

      • Raffaele Palmirotta, Maria Laura De Marchis, Giorgia Ludovici, Patrizia Ferroni, Pasquale Abete, Fiorella Guadagni et al.
      Pages 45-65
    3. Pharmacogenetics of Membrane Transporters: A Review of Current Approaches

      • Tristan M. Sissung, Andrew K. L. Goey, Ariel M. Ley, Jonathan D. Strope, William D. Figg
      Pages 91-120
    4. G Protein-Coupled Receptor Accessory Proteins and Signaling: Pharmacogenomic Insights

      • Miles D. Thompson, David E. C. Cole, Pedro A. Jose, Peter Chidiac
      Pages 121-152
    5. G Protein-Coupled Receptor Mutations and Human Genetic Disease

      • Miles D. Thompson, Geoffrey N. Hendy, Maire E. Percy, Daniel G. Bichet, David E. C. Cole
      Pages 153-187
    6. Pharmacogenetics of the G Protein-Coupled Receptors

      • Miles D. Thompson, David E. C. Cole, Valerie Capra, Katherine A. Siminovitch, G. Enrico Rovati, W. McIntyre Burnham et al.
      Pages 189-242
  3. Clinical Applications of Pharmacogenomics

    1. Front Matter

      Pages 243-243
    2. Pharmacogenomics of Heart Failure

      • Anastasios Lymperopoulos, Faren French
      Pages 245-257
    3. Pharmacogenomics in the Development and Characterization of Atheroprotective Drugs

      • Efi Valanti, Alexandros Tsompanidis, Despina Sanoudou
      Pages 259-300
    4. Pharmacogenomics of Alzheimer’s Disease: Novel Therapeutic Strategies for Drug Development

      • Ramón Cacabelos, Pablo Cacabelos, Clara Torrellas, Iván Tellado, Juan C. Carril
      Pages 323-556
    5. Pharmacogenetics of Antipsychotic Treatment in Schizophrenia

      • Jennie G. Pouget, Daniel J. Müller
      Pages 557-587
    6. Pharmacogenetics of Addiction Therapy

      • David A. Nielsen, Ellen M. Nielsen, Teja Dasari, Catherine J. Spellicy
      Pages 589-624
    7. Pharmacogenetics in Rheumatoid Arthritis

      • Deepali Sen, Jisna R. Paul, Prabha Ranganathan
      Pages 625-660
    8. Pharmacogenomics of Osteoporotic Fractures

      • José A. Riancho, Flor M. Pérez-Campo
      Pages 661-670

About this book

Covering topics from individual molecules to systemic diseases, from basic concepts to advanced technologies, Pharmacogenomics in Drug Discovery and Development , Second Edition provides a practical, state-of-the-art and integrative view of the application of pharmacogenomics in drug discovery and development. A wide range of theoretical and experimental approaches are introduced to meet the problem-solving objectives for understanding the complexity in health and diseases, from laboratory tests to computational analysis. The development of pharmacogenomics represents the evolution of biomedicine from treating the disease itself to treating the malfunction of an individual person, the “root” of diseases. With the change of focus from disease-centered to human-centric medicine, pharmacogenomics brings hope for the transformation from simple disease treatment to accurate prediction and effective prevention. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

 

Authoritative and easily accessible, Pharmacogenomics in Drug Discovery and Development, Second Edition seeks to serve both professionals and novices with comprehensive resources and a holistic view for the translation of pharmacogenomics into better preventive and personalized medical care.

Editors and Affiliations

  • PharmTao, Santa Clara, USA

    Qing Yan

Bibliographic Information

  • Book Title: Pharmacogenomics in Drug Discovery and Development

  • Editors: Qing Yan

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-0956-8

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2014

  • Hardcover ISBN: 978-1-4939-0955-1Published: 23 August 2014

  • Softcover ISBN: 978-1-4939-4758-4Published: 22 September 2016

  • eBook ISBN: 978-1-4939-0956-8Published: 23 August 2014

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 2

  • Number of Pages: XIII, 715

  • Number of Illustrations: 12 b/w illustrations, 32 illustrations in colour

  • Topics: Pharmacology/Toxicology

Buy it now

Buying options

eBook USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access