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Provides step-by-step detail essential for reproducible results
Contains key notes and implementation advice from the experts
Structural Genomics and Drug Discovery: Methods and Protocols focuses on high throughput structure determination methods and how they can be applied to lay the groundwork for structure aided drug discovery. The methods and protocols that are described can be applied in any laboratory interested in using detailed structural information to advance the initial stages of drug discovery.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Structural Genomics and Drug Discovery: Methods and Protocols seeks to aid scientists in the further study intostructural genomics approach as an efficient initial step toward drug discovery and the methods described will be useful to anyone interested in moving in this direction.
Content Level »Professional/practitioner
Keywords »Structural Genomics - bio-informatics - cloning - crystallization screening - data management - drug discovery - expression and solubility testing - genome sequencing - macromolecular structure determination - protein production - purification - screening for suitability for NMR structure determination - structure aided drug discovery - structure determination methods