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Trichloroethylene: Toxicity and Health Risks

  • Book
  • © 2014

Overview

Editors:
  1. Kathleen M. Gilbert

    1. Department of Microbiology and Immunology, Arkansas Children’s Hospital Research Institute, University of Arkansas for Medical Sciences, Little Rock, USA

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  2. Sarah J. Blossom

    1. Department of Pediatrics, Arkansas Children’s Hospital Research Institute, University of Arkansas for Medical Sciences, Little Rock, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • A comprehensive overview of documented and predicted health effects of trichloroethylene exposure
  • Explains how exposure to trichloroethylene may contribute to the etiology of several idiopathic human diseases
  • Discusses the role of epigenetic alterations in trichloroethylene toxicity providing important mechanistic information, it may also provide and the basis for research on intervention therapy

Part of the book series: Molecular and Integrative Toxicology (MOLECUL)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-x
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  2. History of TCE

    • Richard E. Doherty
    Pages 1-14

  3. Trichloroethylene and Autoimmunity in Human and Animal Models

    • Kathleen M. Gilbert
    Pages 15-35

  4. Hypersensitivity Dermatitis and Hepatitis

    • Michihiro Kamijima, Hailan Wang, Osamu Yamanoshita, Yuki Ito, Tamie Nakajima
    Pages 37-52

  5. Trichloroethylene-Induced Oxidative Stress and Autoimmunity

    • M. Firoze Khan, Gangduo Wang
    Pages 53-71

  6. Brain and Behavioral Changes in Rodent Models

    • Ambuja S. Bale
    Pages 73-90

  7. Role of Trichloroethylene in Parkinson’s Disease

    • Samuel M. Goldman, Stephanie Whisnant Cash
    Pages 91-129

  8. Neuroimmune Effects of Developmental TCE Exposure

    • Sarah J. Blossom
    Pages 131-151

  9. Environmental Sensitivity to Trichloroethylene (TCE) in the Developing Heart

    • Ornella I. Selmin, Om Makwana, Raymond B. Runyan
    Pages 153-169

  10. Trichloroethylene and Cancer

    • Daniel Wartenberg, Kathleen M. Gilbert
    Pages 171-184

  11. Epigenetic Alterations due to Trichloroethylene

    • Craig A. Cooney
    Pages 185-208

  12. Mathematical Modeling and Trichloroethylene

    • Brad Reisfeld, Jaime H. Ivy
    Pages 209-237

  13. Back Matter

    Pages 239-245
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Keywords

About this book

A comprehensive overview of the effects of trichloroethylene toxicity caused by real-life exposure levels highlighting how exposure to trichloroethylene may contribute to the etiology of several idiopathic human diseases. Discussion will focus on different kinds of modeling and how they may be used to predict functional consequences and to dissect the contribution of different mechanistic pathways, including potential mechanisms of action for trichloroethylene toxicity in different organ systems. It will explore the role of epigenetic alterations in trichloroethylene toxicity, this provides important mechanistic information and may also provide the basis for intervention therapy. Chapters will also explain how the risks from trichloroethylene exposure may be greater in certain populations based on genetic predisposition, age of exposure and co-exposure to other chemicals With contributions from international experts in the field, Trichloroethylene: Toxicity and Health Risks is an essential resource for researchers and clinicians in toxicology, immunology, medicine and public health as well as industry and government regulatory scientists involved in safety and health protection and epidemiologists, highlighting the need for interdisciplinary cooperation in solving issues of environmental toxicity.

Editors and Affiliations

  • Department of Microbiology and Immunology, Arkansas Children’s Hospital Research Institute, University of Arkansas for Medical Sciences, Little Rock, USA

    Kathleen M. Gilbert

  • Department of Pediatrics, Arkansas Children’s Hospital Research Institute, University of Arkansas for Medical Sciences, Little Rock, USA

    Sarah J. Blossom

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