Trichloroethylene: Toxicity and Health Risks

1. Front Matter

   Pages i-x

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2. History of TCE

   • Richard E. Doherty

   Pages 1-14

3. Trichloroethylene and Autoimmunity in Human and Animal Models

   • Kathleen M. Gilbert

   Pages 15-35

4. Hypersensitivity Dermatitis and Hepatitis

   • Michihiro Kamijima, Hailan Wang, Osamu Yamanoshita, Yuki Ito, Tamie Nakajima

   Pages 37-52

5. Trichloroethylene-Induced Oxidative Stress and Autoimmunity

   • M. Firoze Khan, Gangduo Wang

   Pages 53-71

6. Brain and Behavioral Changes in Rodent Models

   • Ambuja S. Bale

   Pages 73-90

7. Role of Trichloroethylene in Parkinson’s Disease

   • Samuel M. Goldman, Stephanie Whisnant Cash

   Pages 91-129

8. Neuroimmune Effects of Developmental TCE Exposure

   • Sarah J. Blossom

   Pages 131-151

9. Environmental Sensitivity to Trichloroethylene (TCE) in the Developing Heart

   • Ornella I. Selmin, Om Makwana, Raymond B. Runyan

   Pages 153-169

10. Trichloroethylene and Cancer

    • Daniel Wartenberg, Kathleen M. Gilbert

    Pages 171-184

11. Epigenetic Alterations due to Trichloroethylene

    • Craig A. Cooney

    Pages 185-208

12. Mathematical Modeling and Trichloroethylene

    • Brad Reisfeld, Jaime H. Ivy

    Pages 209-237

13. Back Matter

    Pages 239-245

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A comprehensive overview of the effects of trichloroethylene toxicity caused by real-life exposure levels highlighting how exposure to trichloroethylene may contribute to the etiology of several idiopathic human diseases. Discussion will focus on different kinds of modeling and how they may be used to predict functional consequences and to dissect the contribution of different mechanistic pathways, including potential mechanisms of action for trichloroethylene toxicity in different organ systems. It will explore the role of epigenetic alterations in trichloroethylene toxicity, this provides important mechanistic information and may also provide the basis for intervention therapy. Chapters will also explain how the risks from trichloroethylene exposure may be greater in certain populations based on genetic predisposition, age of exposure and co-exposure to other chemicals With contributions from international experts in the field, Trichloroethylene: Toxicity and Health Risks is an essential resource for researchers and clinicians in toxicology, immunology, medicine and public health as well as industry and government regulatory scientists involved in safety and health protection and epidemiologists, highlighting the need for interdisciplinary cooperation in solving issues of environmental toxicity.

• Endocrine
• Epigenetic
• Immunotoxicity
• Nephrotoxicity
• Neurotoxicity
• trichloroethylene

• Department of Microbiology and Immunology, Arkansas Children’s Hospital Research Institute, University of Arkansas for Medical Sciences, Little Rock, USA

  Kathleen M. Gilbert

• Department of Pediatrics, Arkansas Children’s Hospital Research Institute, University of Arkansas for Medical Sciences, Little Rock, USA

  Sarah J. Blossom

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