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Addresses methods of tissue isolation and drug analysis, noninvasive approaches and nanotechnology based products
Presents approaches to assess and model pharmacokinetics of the eye noninvasively as well as a comprehensive coverage of transscleral drug delivery
This comprehensive volume discusses approaches for a systematic selection of delivery systems for various classes of therapeutic agents including small molecule, protein, and nucleic acid drugs. Specific topics covered in this book include:
Solution, suspension, gel, nanoparticle, microparticle, and implant dosage forms
Refillable and microneedle devices
Intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of delivery
Physical methods including iontophoresis for drug delivery
Rational selection of routes of administration and delivery systems
Noninvasive and continuous drug monitoring
Clinical endpoints and regulatory path to drug product development
Emerging and existing drugs and drug targets
Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back of the eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering.
Uday B. Kompella, Ph.D., Professor of Pharmaceutical Sciences & Ophthalmology, University of Colorado, developed functionalized nanoparticles, nanoporous microparticles, microparticles, injectable implants, dendrimers, liposomes, and in situ forming gels for the eye. He is a Fellow of the American Association of Pharmaceutical Scientists (2005) and the Association for Research in Vision and Ophthalmology (2010). He received Distinguished Scientist (2006) Award from the University of Nebraska.
Henry F. Edelhauser, Ph.D., Professor of Ophthalmology, Emory University, made pioneering contributions towards transcorneal, transscleral, and suprachoroidal drug delivery to the eye. He is a recipient of the Castroviejo Medal and the Alcon Research Award (1999), American Academy of Ophthalmology Senior Achievement Award (2000), and the Procter Medal (2005) for his outstanding ophthalmic translational research. He served as the president of the Association for Research in Vision and Ophthalmology (1990-91).
Content Level »Research
Keywords »AAPS - Back - Development - Drug - Edelhauser - Eye - Kompella - Product