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Biomedical Sciences - Pharmacology & Toxicology | Inflammation in the Pathogenesis of Chronic Diseases - The COX-2 Controversy

Inflammation in the Pathogenesis of Chronic Diseases

The COX-2 Controversy

Series: Subcellular Biochemistry, Vol. 42

Harris, Randall E. (Ed.)

2007, XIII, 323 p.

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  • A comprehensive treatise of COX-2, inflammation and disease
  • Offers a spell-binding look at the COX-2 controversy
  • Details new and exciting findings on COX-2 blockade in cancer prevention and therapy as well as the prevention of Alzheimer’s disease and other neurodegenerative conditions
  • Covers COX-2 and the inflammogenesis of cancer

In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives on the discovery and development of aspirin, ibuprofen, and compounds that selectively inhibit COX-2, and the potential for development of new compounds with better efficacy and safety in the 21st century. Specific chapters illuminate the role of inflammatory mechanisms in the pathogenesis of arthritis, cardiovascular disease, cancer, neurodegenerative disease, diabetes mellitus, obesity, and other life-threatening and debilitating conditions. In addition, important findings are documented in cancer research and a special section explores the current evidence supporting the role of COX-2 and inflammation in the development of Alzheimer’s disease and other neurodegenerative conditions and the potential benefit of compounds that modulate COX-2 and other inflammatory cytokin

Content Level » Research

Keywords » Alzheimer's Disease - Cancer - Cardiovascular Disease - Cyclooxygenase-2 (COX-2) - Inflammation - Parkinson - cardiovascular - physiology

Related subjects » Cancer Research - Cardiology & Angiology - Immunology - Neurology - Pathology - Pharmacology & Toxicology

Table of contents 

Preface Contributors I. Historical Perspectives CHAPTER 1. Anti-inflammatory Drugs in the 21st Century K. D. Rainsford, PhD II. Inflammatory Mechanisms of Pathogenesis CHAPTER 2. Nitric oxide synthase and cyclooxygenase interactions in cartilage and meniscus: relationships to joint physiology, arthritis, and tissue repair J. Brice Weinberg, MD, Beverley Fermor, PhD, Farshid Guilak, PhD CHAPTER 3. obesity, inflammation, and vascular disease: The Role of the Adipose Tissue as an Endocrine Organ Paolo Calabro’, MD, Edward T. H. Yeh, MD Chapter 4. COX-2 and THE Inflammogenesis of Cancer Randall E. Harris, MD, PhD CHAPTER 5. Role of COX-2 in Inflammatory AND DEGENERATIVE Brain Diseases Luisa Minghetti, PhD III. Inflammation and Cardiovascular Disease: the Coxib Controversy CHAPTER 6. Cardiovascular Effects of the Selective Cyclooxygenase-2 Inhibitors William B. White, MD CHAPTER 7. COX-2 inhibitors and Cardiovascular Risk Daniel J. Salzberg, MD, Matthew R. Weir, MD CHAPTER 8. A BIOLOGICAL RATIONALE FOR THE CARDIOTOXIC EFFECTS OF ROFECOXIB: COMPARATIVE Analysis with other COX-2 Selective Agents and NSAIDs R. Preston Mason, PhD, Mary F. Walter, PhD, Charles A. Day, Robert F. Jacob, PhD IV. COX-2 Blockade in Cancer Prevention and Therapy CHAPTER 9. Cancer Chemoprevention by COX-2 Blockade: Results of Case Control Studies. Randall E. Harris, MD, PhD, Joanne Beebe-Donk, Galal A. Alshafie, MD, PhD CHAPTER 10. Strategies for Colon Cancer Prevention: Combination of Chemopreventive Agents Bandaru S. Reddy, DVM, PhD V. Inflammation and Neurodegenerative Disease CHAPTER 11. NSAIDs FOR THE Chemoprevention of Alzheimer’s Disease Christine A. Szekely, Ph.D., Terrence Town, Ph.D, Peter P. Zandi,Ph.D CHAPTER 12. Inflammation in Parkinson’s disease: causative or epiphenomenal? Andreas Hald, PhD, Johan van Beek, PhD, and Julie Lotharius, PhD VI. Nutrition, Inflammation and Chronic Disease CHAPTER 13. NUTRITION, INFLAMMATION, AND CARDIOVASCULAR DISEASE Michel de Logeril, MD CHAPTER 14. NUTRITION, INFLAMMATION & bRAIN AGING Frances C. Lau, PhD, Barbara Shukitt-Hale, PhD, James Joseph, PhD INDEX

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