Pharmacology of GABA and Glycine Neurotransmission

1. Front Matter

   Pages I-XXI

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2. Physiology of the Neurotransmitters GABA and Glycine

   1. Front Matter

      Pages 1-1

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   2. Physiology of the GABA and Glycine Systems

      • B. E. Alger, F. E. N. Le Beau

      Pages 3-76

3. Pharmacology of the GABA System

   1. Front Matter

      Pages 77-77

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   2. GABAA Receptors

      1. The Molecular Architecture of GABAA Receptors

         • E. A. Barnard

         Pages 79-99

      2. Functions of GABAA-Receptors: Pharmacology and Pathophysiology

         • H. Möhler

         Pages 101-116

      3. Steroid Modulation of GABAA Receptors

         • J. J. Lambert, J. A. Peters, S. C. Harney, D. Belelli

         Pages 117-140

      4. Allosteric Modulation of GABAA Receptor Function by General Anesthetics and Alcohols

         • M. D. Krasowski, R. A. Harris, N. L. Harrison

         Pages 141-172

      5. Anticonvulsants Acting on the GABA System

         • B. S. Meldrum, P. Whiting

         Pages 173-194

      6. Heterologous Regulation of GABAA Receptors: Protein Phosphorylation

         • T. G. Smart, P. Thomas, N. J. Brandon, S. J. Moss

         Pages 195-225

      7. Tolerance and Dependence to Ligands of the Benzodiazepine Recognition Sites Expressed by GABAA Receptors

         • E. Costa, J. Auta, A. Guidotti

         Pages 227-250

      8. GABAA Receptors and Disease

         • H. Y. Kim, R. W. Olsen

         Pages 251-270

      9. GABAC Receptors: Structure, Function and Pharmacology

         • J. Bormann, A. Feigenspan

         Pages 271-296

   3. GABAB Receptors

      1. Structure of GABAB Receptors

         • B. Bettler, K. Kaupmann

         Pages 299-309

      2. Pharmacology of GABAB Receptors

         • N. G. Bowery

         Pages 311-328

      3. GABAB Receptor Signaling Pathways

         • S. J. Enna

         Pages 329-342

   4. GABA Transporters

      1. Structure and Function of GABA Transporters

         • B. I. Kanner

         Pages 345-354

      2. Pharmacology of GABA Transporters

         • J. E. Clark, W. A. Clark

         Pages 355-372

4. Pharmacology of the Glycine System

   1. Front Matter

      Pages 373-373

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   2. Structures, Diversity and Pharmacology of Glycine Receptors and Transporters

      • H. Betz, R. J. Harvey, P. Schloss

      Pages 375-401

Highlighting the current developments and future directions in GABA and glycine research, this volume covers the major inhibitory neurotransmitters from the molecular mechanisms of signal transduction to their role in health and disease. It is of topical importance because these neurotransmitters are essential for brain function and therapy of diseases such as anxiety disorders, insomnias, epilepsy, depression, spasticity, and memory deficits. Distinguished scientists at the forefront of research contributed reviews on the role of these transmitters in governing neuronal networks, their signalling pathways, their receptors, the pharmacology of GABA A- and GABA B- and GABA C-receptors as well as of GABA- and glycine-transporters, and their role in disease. The volume serves as reference for pharmacologists/toxicologists, neuroscientists, neurologists and psychiatrists.

• Depression
• GABA
• Glycine
• Glycinstoffwechsel
• Inhibitory neurotransmitters
• Neurotransmitter
• pathophysiology
• physiology
• psychopharmacology

• Institute of Pharmacology and Toxicology, ETH and University of Zürich, Zürich, Switzerland

  Hanns Möhler

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