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Apoptosis and Its Modulation by Drugs

  • Book
  • © 2000

Overview

Editors:
  1. Ross G. Cameron

    1. Department of Pathology Toronto Hospital, General Division, University of Toronto, Toronto, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. George Feuer

    1. Banting Institute Department of Clinical Biochemistry, University of Toronto, Toronto, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • This book represents the summation of considerable effort from a significant group of contributors from all over the world as well as from its editors.
  • The message contained is well delineated and will serve as a comprehensive resumé of factors influencing apoptosis.
  • The end result of these efforts wil be significant contributions to health and the adoption of new, never anticipated, therapeutic approaches.

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 142)

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Table of contents (18 chapters)

  1. Front Matter

    Pages I-XXV
    Download chapter PDF

  2. Incidence of Apoptosis and Its Pathological and Biochemical Manifestations

    • R. Cameron, G. Feuer
    Pages 1-35

  3. Molecular Cellular and Tissue Reactions of Apoptosis and Their Modulation by Drugs

    • R. Cameron, G. Feuer
    Pages 37-57

  4. Hepatocyte Apoptosis Triggered by Natural Substances (Cytokines, Other Endogenous Molecules and Foreign Toxins)

    • D. Pessayre, G. Feldmann, D. Haouzi, D. Fau, A. Moreau, M. Neuman
    Pages 59-108

  5. The Role of C-type Protein Kinases in Apoptosis

    • M. Lucas
    Pages 109-126

  6. How Does Programmed Cell Death Contribute to AIDS Pathogenesis?

    • M.-L. Gougeon
    Pages 127-150

  7. Apoptotic Cell Phagocytosis

    • J. Savill, C. Bebb
    Pages 151-177

  8. T Cell Apoptosis and Its Role in Peripheral Tolerance

    • R. Cameron, L. Zhang
    Pages 179-196

  9. Apoptosis of Nerve Cells

    • A.-M. Woodgate, M. Dragunow
    Pages 197-233

  10. Use of p53 as Cancer Cell Target for Gene Therapy

    • C. Thiede, T.D. Kim, A. Neubauer
    Pages 235-255

  11. Antioxidants: Protection Versus Apoptosis

    • Y. Delneste, E. Roelandts, J.-Y. Bonnefoy, P. Jeannin
    Pages 257-273

  12. Reactive Oxygen Species and Apoptosis

    • G. Bauer, S. Dormann, I. Engelmann, A. Schulz, M. Saran
    Pages 275-318

  13. Clearance of Apoptotic Lymphocytes by Human Kupffer Cells. Phagocytosis of Apoptotic Cells in the Liver: Role of Lectin Receptors and Therapeutic Advantages

    • L. Dini
    Pages 319-341

  14. Drug-Induced Apoptosis of Skin Cells and Liver

    • M. Neuman, R. Cameron, N. Shear
    Pages 343-355

  15. Apoptosis and Eosinophils

    • H.-U. Simon
    Pages 357-374

  16. Thymocyte and B-Cell Death Without DNA Fragmentation

    • T. Itoh, M. Nakamura, H. Yagi, H. Soga, T. Ishii
    Pages 375-397

  17. Antigen Receptor-Induced Death of Mature B Lymphocytes

    • T. Defrance, M. Berard, M. Casamayor-Palleja
    Pages 399-427

  18. Modulation of Apoptosis and Maturation of the B-Cell Immune Response

    • G. Koopman
    Pages 429-456

  19. The Neuroprotective and Neuronal Rescue Effect of (-)-Deprenyl

    • K. Magyar, B. Szende
    Pages 457-472

  20. Back Matter

    Pages 473-478
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Keywords

About this book

Apoptosis is a fascinating concept for the basic scientist. This is not only because of the multifaceted variety of proposed and discovered mechanisms, but because apoptosis represents a fundamental pathway for cell renewal. The study of apoptosis has resulted in an array of discoveries on signal transduc­ tion and downstream effects that have facilitated and advanced many fields in biology, including research on cancer and other diseases. Thus, the apoptotic process can be viewed as the largest effort of the scientific community to understand how cells work and tissues assemble or remodel. The most direct consequence of this accumulated knowledge is a greater understanding of disease and pathological mechanisms. The end result of these efforts will be significant contributions to health and the adoption of new, never anticipated, therapeutic approaches. This book represents the summation of considerable effort from a significant group of contributors from all over the world as well as from its editors. In this fashion, many viewpoints have been collected and SUbjected to thorough academic discussion. The concepts contained in this medically important volume will stimulate and renew the ideas of scientists and indeed, will generate additional work to advance biological knowledge even further. The emphasis of this volume cements what has been established, adds what has not been explored fully, and creates a fertile ground for further hypotheses that will lead to a more complete understanding of the apoptotic process.

Editors and Affiliations

  • Department of Pathology Toronto Hospital, General Division, University of Toronto, Toronto, Canada

    Ross G. Cameron

  • Banting Institute Department of Clinical Biochemistry, University of Toronto, Toronto, Canada

    George Feuer

Bibliographic Information

  • Book Title: Apoptosis and Its Modulation by Drugs

  • Editors: Ross G. Cameron, George Feuer

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-57075-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2000

  • Hardcover ISBN: 978-3-540-66121-4Published: 05 January 2000

  • Softcover ISBN: 978-3-642-63025-5Published: 22 November 2012

  • eBook ISBN: 978-3-642-57075-9Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXV, 478

  • Number of Illustrations: 77 b/w illustrations, 3 illustrations in colour

  • Topics: Pharmacology/Toxicology, Human Physiology, Anatomy, Immunology, Cell Biology, Neurosciences

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