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Enzyme Kinetics in Drug Metabolism

Fundamentals and Applications

  • Book
  • © 2014

Overview

Editors:
  1. Swati Nagar

    1. Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Upendra A. Argikar

    1. Novartis Inst. for BioMedical Research, Cambridge, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Donald J. Tweedie

    1. Drug Metabolism, Boehringer Ingelheim, Ridgefield, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Includes clear explanations of fundamentals for correct application
  • Contains key notes, experiences and implementation advice from
  • Covers relevant and current topics including Drug Metabolizing Enzymes and Transporters
  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Molecular Biology (MIMB, volume 1113)

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Table of contents (24 protocols)

  1. Front Matter

    Pages i-xviii
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  2. Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications

    • Swati Nagar, Upendra A. Argikar, Donald J. Tweedie
    Pages 1-6

  3. Fundamentals of Enzyme Kinetics

    1. Front Matter

      Pages 7-7
      Download chapter PDF

    2. Fundamentals of Enzyme Kinetics

      • Eleanore Seibert, Timothy S. Tracy
      Pages 9-22

    3. Different Enzyme Kinetic Models

      • Eleanore Seibert, Timothy S. Tracy
      Pages 23-35

    4. Reversible Mechanisms of Enzyme Inhibition and Resulting Clinical Significance

      • Barbara Ring, Steven A. Wrighton, Michael Mohutsky
      Pages 37-56

    5. Irreversible Enzyme Inhibition Kinetics and Drug–Drug Interactions

      • Michael Mohutsky, Stephen D. Hall
      Pages 57-91

    6. Multienzyme Kinetics and Sequential Metabolism

      • Larry C. Wienkers, Brooke Rock
      Pages 93-118

    7. Consideration of the Unbound Drug Concentration in Enzyme Kinetics

      • Nigel J. Waters, R. Scott Obach, Li Di
      Pages 119-145

  4. Kinetics of Drug Metabolizing Enzymes and Transporters

    1. Front Matter

      Pages 147-147
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    2. Enzyme Kinetics of Oxidative Metabolism: Cytochromes P450

      • Ken Korzekwa
      Pages 149-166

    3. Enzyme Kinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase

      • John T. Barr, Kanika Choughule, Jeffrey P. Jones
      Pages 167-186

    4. Enzyme Kinetics of Conjugating Enzymes: PAPS Sulfotransferase

      • Margaret O. James
      Pages 187-201

    5. Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)

      • Jin Zhou, John O. Miners
      Pages 203-228

    6. Principles and Experimental Considerations for In Vitro Transporter Interaction Assays

      • Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Weiskircher-Hildebrandt, Ismael J. Hidalgo
      Pages 229-252

  6. Variability in Kinetics

    1. Front Matter

      Pages 335-335
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Keywords

About this book

Drug metabolism and transport are very important facets within the discipline of pharmaceutical sciences, with enzyme kinetic concepts utilized regularly in characterizing and modeling the disposition and elimination of drugs. Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications focuses on very practical aspects of applying kinetic principles to drug metabolizing enzymes and transporters. Divided into five convenient sections, topics include the fundamental principles of enzyme kinetics, the kinetics of oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches for both drug metabolizing enzymes and transporters including novel systems biology approaches, understanding of variability both experimental and interindividual (pharmacogenomic), and case studies that provide real life examples of applying these principles. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics especially suitable for the novice, in some cases step-by-step, readily reproducible protocols, and insights to help with troubleshooting and avoiding known pitfalls with extensive cross referencing to assist in learning.

Authoritative and easily accessible, Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications serves as a very practical teaching tool for novice, non-mathematically trained scientists interested in these fundamental concepts and as an aid for their supervisors in teaching these principles.   

Editors and Affiliations

  • Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, USA

    Swati Nagar

  • Novartis Inst. for BioMedical Research, Cambridge, USA

    Upendra A. Argikar

  • Drug Metabolism, Boehringer Ingelheim, Ridgefield, USA

    Donald J. Tweedie

Bibliographic Information

  • Book Title: Enzyme Kinetics in Drug Metabolism

  • Book Subtitle: Fundamentals and Applications

  • Editors: Swati Nagar, Upendra A. Argikar, Donald J. Tweedie

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-62703-758-7

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC 2014

  • Hardcover ISBN: 978-1-62703-757-0Published: 13 February 2014

  • Softcover ISBN: 978-1-4939-6046-0Published: 27 August 2016

  • eBook ISBN: 978-1-62703-758-7Published: 12 February 2014

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XVIII, 538

  • Number of Illustrations: 98 b/w illustrations, 36 illustrations in colour

  • Topics: Pharmacology/Toxicology, Enzymology

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