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Opiate Receptors and Antagonists

From Bench to Clinic

  • Book
  • © 2009

Overview

Editors:
  1. Reginald L. Dean

    1. Life Sciences/Toxicology, Alkermes, Inc., Cambridge, USA

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  2. Edward J. Bilsky

    1. Department of Pharmacology, College of Osteopathic Medicine, University of New England, Biddleford, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. S. Stevens Negus

    1. Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Summarizes the present understanding of the chemistry, pharmacology and molecular biology of opioid receptors and their subtypes
  • Highlights differences and similarities between the opioid pharmacology of animals and human
  • Describes current and potential therapeutic areas for opioid antagonists, including substance abuse, alcohol and ingestive behaviors, behavioral disorders and other medical indications, supported by nonclinical and clinical evidence
  • Focuses on the development of exciting and innovative drug delivery approaches that are being used with opioid antagonists for the above medical indications

Part of the book series: Contemporary Neuroscience (CNEURO)

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Table of contents (39 chapters)

  1. Front Matter

    Pages i-xxiii
    Download chapter PDF

  2. Opioid Receptors

    1. Ultra-Low-Dose Opioid Antagonists Enhance Opioid Analgesia and Reduce Tolerance

      • Lindsay H. Burns, Todd W. Vanderah, Hoau-Yan Wang
      Pages 3-17

    2. Upregulation of Opioid Receptors

      • Ellen M. Unterwald, Richard D. Howells
      Pages 19-44

    3. Imaging Human Brain Opioid Receptors: Applications to Substance Use Disorders

      • Mark K. Greenwald, Caren L. Steinmiller
      Pages 45-65

    4. Opioid Receptor Antagonist-Mediated Signaling in the Immune System

      • Jonathan Moorman, Zhi Qiang Yao, Edward J. Bilsky, Deling Yin
      Pages 67-80

  3. Opioid Antagonists: Chemistry and Pharmacology

    1. The Chemistry and Pharmacology of μ-Opioid Antagonists

      • Jean M. Bidlack, Jennifer L. Mathews
      Pages 83-97

    2. Medicinal Chemistry of Kappa Opioid Receptor Antagonists

      • Cécile Béguin, Bruce M. Cohen
      Pages 99-118

    3. The Chemistry and Pharmacology of Delta Opioid Antagonists

      • Beatriz Fioravanti, Todd W. Vanderah
      Pages 119-136

    4. Novel Opioid Antagonists with Mixed/Dual Selectivity

      • Richard B. Rothman, Subramaniam Ananthan, Edward J. Bilsky
      Pages 137-151

    5. Experimental Utility and Clinical Potential of Irreversible Opioid Antagonists

      • Ellen A. Walker, Sandra D. Comer
      Pages 153-174

    6. Methylnaltrexone: A Peripherally Acting Opioid Antagonist

      • Chun-Su Yuan, Robert J. Israel
      Pages 175-198

  4. Substance Abuse

    1. Opioid Antagonist Effects in Animal Models Related to Opioid Abuse: Drug Discrimination and Drug Self-Administration

      • S. Stevens Negus
      Pages 201-226

    2. Naltrexone for Initiation and Maintenance of Opiate Abstinence

      • Kevin A. Sevarino, Thomas R. Kosten
      Pages 227-245

    3. Ultra-Low-Dose Naltrexone Decreases Dependence and Addictive Properties of Opioids

      • Lindsay H. Burns, Francesco Leri, Mary C. Olmstead
      Pages 247-261

    4. Can a Combination Formulation Containing a Neutral Opiate Antagonist Decrease the Abuse of μ-Agonist Opiates

      • John Mendelson, Mark Pletcher, Gantt Galloway
      Pages 263-272

    5. Effects of Opioid Antagonists on the Abuse-Related Effects of Psychomotor Stimulants and Nicotine

      • Brenda J. Gehrke, GehrkeToni S. Shippenberg
      Pages 273-298

    6. Potential Use of Opioid Antagonists in the Treatment of Marijuana Abuse and Dependence

      • B. Le Foll, Zuzana Justinova, G. Tanda, Marcello Solinas, Peter Selby, Steven R. Goldberg
      Pages 299-314

    7. Naltrexone in Smoking Cessation: A Review of the Literature and Future Directions

      • Andrea King, Rachel Torello, Suchitra Krishnan-Sarin, Stephanie O'Malley
      Pages 315-332
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Keywords

About this book

The evolution in our understanding of opioid receptors and their subtypes is in- mately linked to the development of new pharmacological treatments for diseases/ disorders as diverse as addiction, self-injurious behavior, pain, cancer, infl- mation, eating disorders, traumatic injury, pruritis, and movement disorders. These potential treatments involve both novel chemical entities and classic opioid antagonists with improved drug delivery systems. The contributions contained in Opioid Receptors and Antagonists: From Bench to Clinic represent the efforts from some of the leading international scientists and clinicians making use of the l- est information emerging from the study of the opioid receptor system. Given the number of researchers currently active in this and related fields of study, it would be inappropriate to suggest that the entire range of activities is fully reflected in this single volume. Instead, a variety of experimental and clinical approaches involving the fields of neuroscience, molecular biology, biochemistry, anatomy, pharmacology, psychology, and psychiatry have been chosen to illustrate rapidly developing experimental and therapeutic areas.

Reviews

From the reviews:

“The authors do an excellent job of providing insight into the background of the many factors related to opioid receptor antagonists. … Overall, this work is a well written and interesting text and would be a very useful addition to the personal libraries of those medicinal chemists with a research interest in the modulation of the opioid receptor system.” (Thomas E. Prisinzano, Journal of Medicinal Chemistry, Vol. 53 (2), March, 2010)

“This book is focused on the therapeutic uses of opioid antagonists ranging from classical opioid antagonists to novel chemical entities. In any therapeutic field examined, the aim of book as outlined by the title–‘From Bench to Clinic’–is achieved. … The clinical applications of opioid antagonists are extensively discussed in almost all chapters of this book … . In conclusion, this book gives an interesting analysis of the different fields of knowledge and research concerning therapeutic uses of opioid antagonists in recent years.” (Agostino Marrazzo, ChemBioChem, Vol. 5, 2010)

Editors and Affiliations

  • Life Sciences/Toxicology, Alkermes, Inc., Cambridge, USA

    Reginald L. Dean

  • Department of Pharmacology, College of Osteopathic Medicine, University of New England, Biddleford, USA

    Edward J. Bilsky

  • Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, USA

    S. Stevens Negus

Bibliographic Information

  • Book Title: Opiate Receptors and Antagonists

  • Book Subtitle: From Bench to Clinic

  • Editors: Reginald L. Dean, Edward J. Bilsky, S. Stevens Negus

  • Series Title: Contemporary Neuroscience

  • DOI: https://doi.org/10.1007/978-1-59745-197-0

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2009

  • Hardcover ISBN: 978-1-58829-881-2Published: 09 March 2009

  • Softcover ISBN: 978-1-61737-822-5Published: 19 November 2010

  • eBook ISBN: 978-1-59745-197-0Published: 12 March 2009

  • Edition Number: 1

  • Number of Pages: XXIII, 757

  • Topics: Pharmacology/Toxicology

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