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Models for Assessing Drug Absorption and Metabolism

  • Book
  • © 1996

Overview

Editors:
  1. Ronald T. Borchardt

    1. The University of Kansas, Lawrence, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Philip L. Smith

    1. SmithKline Beecham Pharmaceuticals, King of Prussia, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Glynn Wilson

    1. Tacora Corporation, Seattle, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Pharmaceutical Biotechnology (PBIO, volume 8)

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xxii
    Download chapter PDF

  2. General Principles in the Characterization and Use of Model Systems for Biopharmaceutical Studies

    • Ronald T. Borchardt, Philip L. Smith, Glynn Wilson
    Pages 1-11

  3. Methods for Evaluating Intestinal Permeability and Metabolism in Vitro

    • Philip L. Smith
    Pages 13-34

  4. Cultured Intestinal Epithelial Cell Models

    • Ismael J. Hidalgo
    Pages 35-50

  5. Intestinal Rings and Isolated Intestinal Mucosal Cells

    • Joseph A. Fix
    Pages 51-66

  6. Models of Drug Absorption in Situ and in Conscious Animals

    • Robin Griffiths, Ann Lewis, Phillip Jeffrey
    Pages 67-84

  7. Model Systems for Intestinal Lymphatic Transport Studies

    • Christopher J. H. Porter, William N. Charman
    Pages 85-102

  8. Buccal Tissues and Cell Culture

    • Elizabeth Quadros, James P. Cassidy, Harry Leipold
    Pages 103-113

  9. Isolated Hepatocytes

    • M. Vore, Y. Liu, T. C. Ganguly
    Pages 115-120

  10. Cultured Rat Hepatocytes

    • Edward L. LeCluyse, Peter L. Bullock, Andrew Parkinson, Jerome H. Hochman
    Pages 121-159

  11. Isolated Perfused Liver

    • Kim L. R. Brouwer, Ronald G. Thurman
    Pages 161-192

  12. Isolated Renal Brush Border and Basolateral Membrane Vesicles and Cultured Renal Cells

    • Marcelo M. Gutierrez, Claire M. Brett, Kathleen M. Giacomini
    Pages 193-210

  13. Use of an Isolated Perfused Kidney to Assess Renal Clearance of Drugs

    • Noriko Okudaira, Yuichi Sugiyama
    Pages 211-238

  14. Brain Microvessel Endothelial Cell Culture Systems

    • Kenneth L. Audus, Lawrence Ng, Wen Wang, Ronald T. Borchardt
    Pages 239-258

  15. Methods to Study Drug Transport in Isolated Choroid Plexus Tissue and Cultured Cells

    • Carla B. Washington, Kathleen M. Giacomini, Claire M. Brett
    Pages 259-283

  16. Brain Perfusion Systems for Studies of Drug Uptake and Metabolism in the Central Nervous System

    • Quentin R. Smith
    Pages 285-307

  17. In Vitro Nasal Models

    • Patricia M. Reardon
    Pages 309-323

  18. Models for Investigation of Peptide and Protein Transport across Cultured Mammalian Respiratory Epithelial Barriers

    • Kwang-Jin Kim, Edward D. Crandall
    Pages 325-346

  19. Drug Transport across Xenopus Alveolar Epithelium in Vitro

    • Doris Wall, Doreen Pierdomenico
    Pages 347-359

  20. In Situ and in Vivo Methods for Pulmonary Delivery

    • Mohammed Eljamal, Sudha Nagarajan, John S. Patton
    Pages 361-374
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Keywords

About this book

Pharmaceutical scientists in industry and academia will appreciate this single reference for its detailed experimental procedures for conducting biopharmaceutical studies. This well-illustrated guide allows them to establish, validate, and implement commonly used in situ and in vitro model systems. Chapters provide ready access to these methodologies for studies of the intestinal, buccal, nasal and respiratory, vaginal, ocular, and dermal epithelium as well as the endothelial and elimination barriers.

Editors and Affiliations

  • The University of Kansas, Lawrence, USA

    Ronald T. Borchardt

  • SmithKline Beecham Pharmaceuticals, King of Prussia, USA

    Philip L. Smith

  • Tacora Corporation, Seattle, USA

    Glynn Wilson

Bibliographic Information

  • Book Title: Models for Assessing Drug Absorption and Metabolism

  • Editors: Ronald T. Borchardt, Philip L. Smith, Glynn Wilson

  • Series Title: Pharmaceutical Biotechnology

  • DOI: https://doi.org/10.1007/978-1-4899-1863-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1996

  • Hardcover ISBN: 978-0-306-45243-7Published: 31 August 1996

  • Softcover ISBN: 978-1-4899-1865-9Published: 12 June 2013

  • eBook ISBN: 978-1-4899-1863-5Published: 29 June 2013

  • Series ISSN: 1078-0467

  • Edition Number: 1

  • Number of Pages: XXII, 444

  • Topics: Pharmacology/Toxicology, Pharmacy

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