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  • Reference work
  • © 2013

Handbook of the Cerebellum and Cerebellar Disorders

Editors:

  1. Mario Manto

    1. Unité d'Etude du Mouvement (UEM), FNRS, Neurologie ULB Erasme, Bruxelles, Belgium

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  2. Jeremy D. Schmahmann

    1. Ataxia Unit, Cognitive and Behavioral Neurology Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA

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  3. Ferdinando Rossi

    1. Neuroscience Institute of the Cavalieri-Ottolenghi Foundation (NICO), University of Turin, Orbassano, Italy

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  4. Donna L. Gruol

    1. Molecular and Integrative Neuroscience Department (MIND), The Scripps Research Institute, California, USA

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  5. Noriyuki Koibuchi

    1. Department of Integrative Physiolgy, Gunma University Graduate School of Medicine, Maebashi, Japan

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  • First major reference in the area of cerebellar research
  • Uniquely available in both print and enhanced electronic formats
  • Produced in conjunction with the Society for Research on the Cerebellum
  • Includes supplementary material: sn.pub/extras

Sections

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Table of contents (106 entries)

  1. Front Matter

    Pages i-xxxiii
    PDF

  2. Section 1 Cerebellar Development

    1. Front Matter

      Pages 1-1
      PDF

    3. Proneural Genes and Cerebellar Neurogenesis in the Ventricular Zone and Upper Rhombic Lip

      • G. Giacomo Consalez, Marta Florio, Luca Massimino, Laura Croci
      Pages 23-41

    4. Zones and Stripes: Development of Cerebellar Topography

      • Roy V. Sillitoe, Richard Hawkes
      Pages 43-59

    5. Roof Plate in Cerebellar Neurogenesis

      • Victor V. Chizhikov
      Pages 61-74

    6. Specification of Cerebellar and Precerebellar Neurons

      • Mikio Hoshino, Yusuke Seto, Mayumi Yamada
      Pages 75-87

    7. Specification of Granule Cells and Purkinje Cells

      • Thomas Butts, Leigh Wilson, Richard J. T. Wingate
      Pages 89-106

    8. Granule Cell Migration and Differentiation

      • Yutaro Komuro, Jennifer K. Fahrion, Kathryn D. Foote, Kathleen B. Fenner, Tatsuro Kumada, Nobuhiko Ohno et al.
      Pages 107-125

    10. Purkinje Cell Migration and Differentiation

      • Constantino Sotelo, Ferdinando Rossi
      Pages 147-178

    11. Development of Cerebellar Nuclei

      • Gina E. Elsen, Gordana Juric-Sekhar, Ray A. M. Daza, Robert F. Hevner
      Pages 179-205

    13. Development of Glutamatergic and GABAergic Synapses

      • Marco Sassoè-Pognetto, Annarita Patrizi
      Pages 237-255

    14. Synaptic Remodeling and Neosynaptogenesis

      • Ann M. Lohof, Mathieu Letellier, Jean Mariani, Rachel M. Sherrard
      Pages 257-279

    15. Synaptogenesis and Synapse Elimination

      • Masanobu Kano, Masahiko Watanabe
      Pages 281-299

    16. Genes and Cell Type Specification in Cerebellar Development

      • Matt Larouche, Daniel Goldowitz
      Pages 301-317

    17. Hormones and Cerebellar Development

      • Noriyuki Koibuchi, Yayoi Ikeda
      Pages 319-339

  3. Section 2 Anatomy, Connections and Neuroimaging of the Cerebellum

    1. Front Matter

      Pages 341-341
      PDF
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About this book

Our knowledge of cerebellar functions and cerebellar disorders, called ataxias, is increasing considerably. Studies of the cerebellum are now a central focus in neuroscience. During the last four decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and biology of mental processes, behavioral symptoms, and emotion. It is now accepted that the cerebellum acts as a cognitive operator in learning, perception, and attention. Moreover, major improvements in our assessment of in vivo cerebellar architecture using imaging techniques have occurred. A typical example is the accurate description of cerebellar anatomy during fetal development with MRI, a progress which has direct impacts on patient care. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias. More than 20 new genes have been identified these last 10 years. Only for dominant ataxias, more than 30 diseases have now been unravelled. The number of ataxic disorders will increase with aging, the cerebellum being the structure of the brain with the most important loss of neurons with age. More than 300 different cerebellar disorders are encountered during daily practice, but we are missing a single source of information explaining their pathogenesis. Despite the immense amount of knowledge acquired about the cerebellar circuitry these last years, a large book covering the neuroscience of the cerebellum is missing. The goal of this endeavour is to bring up to date information relevant for basic science and also for clinical activities. To reach this goal, the most renowned authors are gathered in a unique and in-depth book with a format of a handbook. We emphasize the connections between molecular findings, imaging features, behavioural/neuropsychological aspects, and clinical implications. 
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Keywords

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Reviews

From the reviews:

“The Handbook of the Cerebellum and Cerebellar Disorders represents a monumental effort on the part of the editors and the contributors of the individual chapters to bring to fruition a single set of books that covers almost any aspect of the cerebellum that one can imagine. … It is a reference source that should be found in the library of the serious contemporary neurobiologist, especially those with interest in the cerebellum and its myriad of related brainstem nuclei.” (Duane E. Haines, The Cerebellum, Vol. 13, 2014)

“The editors sought to provide a thorough summary of the current understanding of the cerebellum and its disorders. … It is intended for all audiences who may have an interest in the cerebellum, its function, and its disorders. It can be used by literally all healthcare professionals and neuroscientists. … This is a must have for any university, medical center, or healthcare facility. It is an important addition to the literature and the content is appropriate for all audiences.” (Joseph I. Sirven, Doody’s Book Reviews, October, 2012)
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Editors and Affiliations

  • Unité d'Etude du Mouvement (UEM), FNRS, Neurologie ULB Erasme, Bruxelles, Belgium

    Mario Manto

  • Ataxia Unit, Cognitive and Behavioral Neurology Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA

    Jeremy D. Schmahmann

  • Neuroscience Institute of the Cavalieri-Ottolenghi Foundation (NICO), University of Turin, Orbassano, Italy

    Ferdinando Rossi

  • Molecular and Integrative Neuroscience Department (MIND), The Scripps Research Institute, California, USA

    Donna L. Gruol

  • Department of Integrative Physiolgy, Gunma University Graduate School of Medicine, Maebashi, Japan

    Noriyuki Koibuchi

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About the editors

M. Manto is neurologist. He is researcher at the FNRS-Belgium. He is the founding and current editor of the international journal The Cerebellum (Springer). He is the President of the Medical Board of Euro-Ataxia. He has founded the Society for Research on the Cerebellum (www.socrecer.org).

Our laboratory is funded by national and international research organisations:

-FNRS, Belgium

-Brussels Region

-European Commission (FP5, FP6)

-NIH-USA

Works carried out so far have been published in international peer-reviewed journals.

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Bibliographic Information

  • Book Title: Handbook of the Cerebellum and Cerebellar Disorders

  • Editors: Mario Manto, Jeremy D. Schmahmann, Ferdinando Rossi, Donna L. Gruol, Noriyuki Koibuchi

  • DOI: https://doi.org/10.1007/978-94-007-1333-8

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Reference Module Biomedical and Life Sciences

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature B.V. 2013

  • Hardcover ISBN: 978-94-007-1332-1Published: 04 August 2012

  • eBook ISBN: 978-94-007-1333-8Published: 14 September 2012

  • Edition Number: 1

  • Number of Pages: XXXIV, 2424

  • Number of Illustrations: 50 b/w illustrations, 400 illustrations in colour

  • Additional Information: 4 volumes, not available separately.

  • Topics: Neurosciences, Neurochemistry, Neurobiology, Neurology, Neurosurgery, Human Physiology

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