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Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease

  • Book
  • © 2015

Overview

Editors:
  1. Hoa Huu Phuc Nguyen

    1. Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tübingen, Germany

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  2. M. Angela Cenci

    1. Dept of Experimental Medical Science, Lund University, Lund, Sweden

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    You can also search for this editor in PubMed   Google Scholar

  • Gives an overview of the clinical aspects of Huntington’s Disease (HD) and Parkinson’s Disease (PD) and reviews the construct, face and predictive validity of animal models
  • Provides information on which model to choose for specific research questions and on how they can be used for therapeutic target validation and treatment trials
  • Written by renowned researchers in the field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Topics in Behavioral Neurosciences (CTBN, volume 22)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Clinical Aspects of Huntington’s Disease

    • Rhia Ghosh, Sarah J. Tabrizi
    Pages 3-31

  3. The Neuropathology of Huntington’s Disease

    • Henry J. Waldvogel, Eric H. Kim, Lynette J. Tippett, Jean-Paul G. Vonsattel, Richard LM Faull
    Pages 33-80

  4. Neurobiology of Huntington’s Disease

    • Rebecca A. G. De Souza, Blair R. Leavitt
    Pages 81-100

  5. Mouse Models of Huntington’s Disease

    • Simon P. Brooks, Stephen B. Dunnett
    Pages 101-133

  6. Transgenic Rat Models of Huntington’s Disease

    • João Casaca Carreira, Ali Jahanshahi, Dagmar Zeef, Ersoy Kocabicak, Rinske Vlamings, Stephan von Hörsten et al.
    Pages 135-147

  7. Large Animal Models of Huntington’s Disease

    • Xiao-Jiang Li, Shihua Li
    Pages 149-160

  8. Therapeutic Strategies for Huntington’s Disease

    • Ladislav Mrzljak, Ignacio Munoz-Sanjuan
    Pages 161-201

  9. Clinical and Pathological Features of Parkinson’s Disease

    • Susanne A. Schneider, Jose A. Obeso
    Pages 205-220

  10. Symptomatic Models of Parkinson’s Disease and L-DOPA-Induced Dyskinesia in Non-human Primates

    • Tom M. Johnston, Susan H. Fox
    Pages 221-235

  11. Neuroinflammation in Parkinson’s Disease Animal Models: A Cell Stress Response or a Step in Neurodegeneration?

    • Carolina Cebrián, John D. Loike, David Sulzer
    Pages 237-270

  12. Viral Vector-Based Models of Parkinson’s Disease

    • Anke Van der Perren, Chris Van den Haute, Veerle Baekelandt
    Pages 271-301

  13. Transgenic Rodent Models to Study Alpha-Synuclein Pathogenesis, with a Focus on Cognitive Deficits

    • Asa Hatami, Marie-Francoise Chesselet
    Pages 303-330

  14. Modeling LRRK2 Pathobiology in Parkinson’s Disease: From Yeast to Rodents

    • Guillaume Daniel, Darren J. Moore
    Pages 331-368

  15. Models of Multiple System Atrophy

    • Lisa Fellner, Gregor K. Wenning, Nadia Stefanova
    Pages 369-393

  16. Back Matter

    Pages 395-397
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Keywords

About this book

Motor dysfunction and cognitive impairment are major symptoms in both Huntington’s Disease (HD) and Parkinson’s Disease (PD). A breakthrough in HD research was the identification of the gene that causes this devastating monogenetic illness. Similarly, several genes were found to cause familial forms of PD. With their identification, a plethora of genetic animal models has been generated and has revolutionized the understanding of the pathobiology and pathophysiology of these disorders. The models allow us to study the earliest manifestations of the diseases behaviorally and neuropathologically and help us understand how they progress over time. Additionally, neurotoxic animal models are still of high interest to the PD field, as they are being used to study e.g. mitochondrial dysfunction in PD. This book focuses on animal models of both diseases and how they have helped and will continue to help understand the behavioral neurobiology in these disorders.

Editors and Affiliations

  • Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tübingen, Germany

    Hoa Huu Phuc Nguyen

  • Dept of Experimental Medical Science, Lund University, Lund, Sweden

    M. Angela Cenci

Bibliographic Information

  • Book Title: Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease

  • Editors: Hoa Huu Phuc Nguyen, M. Angela Cenci

  • Series Title: Current Topics in Behavioral Neurosciences

  • DOI: https://doi.org/10.1007/978-3-662-46344-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2015

  • Hardcover ISBN: 978-3-662-46343-7Published: 09 June 2015

  • Softcover ISBN: 978-3-662-52412-1Published: 29 October 2016

  • eBook ISBN: 978-3-662-46344-4Published: 23 May 2015

  • Series ISSN: 1866-3370

  • Series E-ISSN: 1866-3389

  • Edition Number: 1

  • Number of Pages: XIII, 397

  • Number of Illustrations: 70 b/w illustrations, 25 illustrations in colour

  • Topics: Neurosciences, Human Genetics, Neurobiology, Cell Biology

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