Softcover reprint of the original 1st ed. 1997, IX, 334 pp. 75 figs.
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Even though transmitter release and re-uptake are very complementary and physically in close proximity, researchers usually focus on only one of these two aspects. This volume, however, covers both processes and brings together two major presynaptic events in transcellular communication. It comprises 24 chapters and is divided into two parts: Part I, Neurotransmitter Release, and Part II, Neurotransmitter Uptake. The included topics range from ultrastructure and molecular control mechanisms to pathophysiology of some diseased states. Neuronal as well as non-neuronal mechanisms are treated. The concluding chapter emphasizes the importance of interdisciplinary collaboration and provides a link between the events in the presynaptic terminal and behavior.
I: Neurotransmitter Release.- Proteins Implicated in Neurotransmitter Release and Reuptake.- Ion Channels in Transmitter Release.- Fluorescence and Confocal Microscopy.- Calcium Confocal Microscopy of Single Synaptic Boutons.- Practical Aspects of Near-Field Optical Microscopy.- The Mediatophore, A Molecule Involved in Quantal Neurotransmitter Release.- Stimulation of Exocytosis in Cultured Cerebellar Granule Cells by Electrical Field Stimulation.- Modulation of Synaptic NMDA Current by Hydrogen Ion and Histamine in Hippocampal Slices.- Maturation of Pre- and Post-Synaptic Compartments in Hippocampal Neurons Developing in Culture.- GABAB Receptor Control of Neurotransmitter Release in Mammalian Brain: Modification During Chronic Inflammation.- Phosphoproteins and the Regulation of Vesicular Neurotransmitter Release.- Acetylcholine Release From Mouse Neuroblastoma Cells Co-Transfected with Mediatophore and Choline Acetyltransferase cDNAs.- Neurotransmitter Release: An Overview.- II: Neurotransmitter Uptake.- The Vesicular and Plasmalemmal Dopamine Transporters: Ultrastructural Localization in Nigrostriatal Dopaminergic Neurons.- Neurotransmitter Transporters: Is Glycosylation Necessary for Function?.- Dopamine Transporter: Function and Imaging.- Turnover of Rat Dopamine Transporter Protein in rDAT-LLC-PK 1 Cells.- Neurotransporters at the Juncture of Drug Action: Role in Programmed Cell Death, and Toxicity of Abused MDMA.- Voltammetric Studies on the Kinetics and Mechanism of Catecholamine Transporters.- Coupling of Glutamate Uptake and Degradation in Transmitter Clearance: Anatomical Evidence.- Modulation of Neurotransmitter Uptake.- Catalytic and Non-Catalytic Activities of Acetylcholinesterase Implied from Transgenic ACHE Expression in Vertebrates.- Molecular Dissection of Protein Domains Directing the Tissue Targeting of Acetylcholinesterase Isoforms.- Interdisciplinary Interactions Across the Biobehavioral Divide: A Pre-Socratic Perspective.- Author Index.