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The Living Brain and Alzheimer’s Disease

  • Conference proceedings
  • © 2004

Overview

Editors:
  1. Bradley T. Hyman

    1. Neurology Service, Warren 408, Massachusetts General Hospital/Harvard Medical School, Boston, USA

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  2. Jean-François Demonet

    1. Service Neurologie - Inserm U.455, CHU Hôpital Purpan, Toulouse Cedex 3, France

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  3. Yves Christen

    1. Fondation IPSEN, Pour la Recherche Thérapeutique, Paris Cedex 16, France

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Part of the book series: Research and Perspectives in Alzheimer's Disease (ALZHEIMER)

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Table of contents (12 papers)

  1. Front Matter

    Pages I-XV
    Download chapter PDF

  2. Neuropathology of Alzheimer’s Disease, as Seen in Fixed Tissues

    • Charles Duyckaerts, Dominique Langui, Nadège Girardot, Jean-Jacques Hauw, Benoît Delatour
    Pages 1-15

  3. Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer’s Disease

    • Andreas Papassotiropoulos, Alessia Maddalena, Danielle Gretener, Roger M. Nitsch, Christoph Hock
    Pages 17-24

  4. The Living Brain and Alzheimer’s Disease

    • Bradley T. Hyman
    Pages 25-31

  5. In Vivo Imaging of Alzheimer Pathology in Transgenic Mice using Multiphoton Microscopy

    • Brian J. Bacskai, William E. Klunk, Gregory A. Hickey, Jesse Skoch, Stephen T. Kajdasz, Megan E. McLellan et al.
    Pages 33-45

  6. In Vivo Magnetic Resonance of Amyloid Plaques in Alzheimer’s Disease Model Mice

    • Einar M. Sigurdsson, Youssef Zaim Wadghiri, Marcin Sadowski, James I. Elliott, Yongsheng Li, Henrieta Scholtzova et al.
    Pages 47-59

  7. Measuring Progression in Alzheimer’s Disease using Serial MRI: 4D MRI

    • N. C. Fox, J. M. Schott, R. I. Scahill
    Pages 61-74

  8. Validating MRI Measures of Disease Stage and Progression in Alzheimer’s Disease

    • Clifford R. Jack Jr.
    Pages 75-86

  9. Dynamic Mapping of Alzheimer’s Disease

    • Paul M. Thompson, Kiralee M. Hayashi, Greig de Zubicaray, Andrew L. Janke, Elizabeth R. Sowell, Stephen E. Rose et al.
    Pages 87-112

  10. Development of Benzothiazole Amyloid-Imaging Agents

    • William E. Klunk, Yanming Wang, Chester A. Mathis
    Pages 113-122

  11. First PET Study with a Benzothiazol Amyloidimaging Agent (PIB) in Alzheimer’s Disease Patients and Healthy Volunteers

    • Henry Engler, William Klunk, Agneta Nordberg, Gunnar Blomqvist, Daniel Holt, Yanming Wang et al.
    Pages 123-137

  12. Mild Cognitive Impairment (MCI): Predicting Conversion to Clinically Probable Alzheimer’s Disease with Fluoro-Deoxy-Glucose PET

    • J.-C. Baron, G. Chételat, B. Desgranges, F. Eustache
    Pages 139-150

  13. Positron Emission Tomography and Magnetic Resonance Imaging in the Study of Cognitively Normal Persons at Differential Genetic Risk for Alzheimer’s Dementia

    • Eric M. Reiman, Richard J. Caselli, Kewei Chen, Gene E. Alexander
    Pages 151-177

  14. Back Matter

    Pages 179-180
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Keywords

About this book

From large cross-sectional studies of autopsy material, it seems as if a time course of Alzheimer's Disease, at least on average, can be mapped out: a pattern of hierarchical vulnerability for neuronal loss and neurofibrillary tangles beginning in medial temporal lobe structures proceeding through association areas. Plaques follow their own temporal course, with widespread cortical deposits occurring even early in a disease process. The whole process may well take twenty years, the first half of which may be without overt symptoms.

Editors and Affiliations

  • Neurology Service, Warren 408, Massachusetts General Hospital/Harvard Medical School, Boston, USA

    Bradley T. Hyman

  • Service Neurologie - Inserm U.455, CHU Hôpital Purpan, Toulouse Cedex 3, France

    Jean-François Demonet

  • Fondation IPSEN, Pour la Recherche Thérapeutique, Paris Cedex 16, France

    Yves Christen

Bibliographic Information

  • Book Title: The Living Brain and Alzheimer’s Disease

  • Editors: Bradley T. Hyman, Jean-François Demonet, Yves Christen

  • Series Title: Research and Perspectives in Alzheimer's Disease

  • DOI: https://doi.org/10.1007/978-3-642-59300-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2004

  • Softcover ISBN: 978-3-642-63927-2Published: 15 April 2014

  • eBook ISBN: 978-3-642-59300-0Published: 06 December 2012

  • Series ISSN: 0945-6066

  • Series E-ISSN: 2196-310X

  • Edition Number: 1

  • Number of Pages: XV, 180

  • Number of Illustrations: 17 b/w illustrations, 33 illustrations in colour

  • Topics: Neurosciences

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