Overview
- Editors:
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Donald W. Pfaff
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, Lab. of Biochem. and Molec. Biology, The Rockefeller University, New York, USA
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Yves Christen
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Fondation Ipsen, Boulogne Billancourt, France
- Latest research on epigenetics and brain development
- Presents animal and human studies
- Written by leading international experts in the field
- Includes supplementary material: sn.pub/extras
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Table of contents (11 chapters)
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Front Matter
Pages i-xiii
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- Khatuna Gagnidze, Donald W. Pfaff
Pages 1-19
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- Catherine Dulac, Gregg Christopher
Pages 35-41
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- Javier DeFelipe, Lidia Alonso-Nanclares
Pages 43-57
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- Francesca Ducci, Laura Bevilacqua, Paola Landi, David Goldman
Pages 81-102
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- James M. Swanson, Kimberly D. Lakes, Tim L. Wigal, Nora D. Volkow
Pages 103-122
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- Bonnie Auyeung, Simon Baron-Cohen
Pages 123-137
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- Jill M. Goldstein, Laura M. Holsen, Robert Handa, Stuart Tobet
Pages 139-163
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- Phyllis M. Wise, Candice M. Brown, Jodi L. Downs
Pages 165-178
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Back Matter
Pages 179-181
About this book
In theoretical terms, sex differences in brains and behaviors of laboratory animals offer the possibility of fascinating scientific studies on a range of molecular phenomena such as genomic imprinting, DNA methylation, chromatin protein modification, non-coding DNA, potentially resulting in important neuroanatomical and neurochemical sex differences in the brain. Such sex differences could arise consequent to exposures to testosterone early in development, or to other effects deriving from the Y chromosome. However, this general subject has been treated with much hyperbole. Historically, sex differences were assumed to be present where they did not really exist, e.g. with respect to mathematics, executive leadership, etc. etc. Under what circumstances do we really care about sex differences in brain and behavior? These circumstances concern human maladies whose diagnoses are much different between boys and girls, or between women and men. Prominent examples discussed in this volume include autism, attention deficit hyperactivity disorders and congenital adrenal hyperplasia. In fact, infant boys are more susceptible than infant girls to a variety of disorders that arise early in development. This volume then ends with a consideration of effects of estrogenic hormones on the injured brain, and their roles as protective agents.
Editors and Affiliations
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, Lab. of Biochem. and Molec. Biology, The Rockefeller University, New York, USA
Donald W. Pfaff
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Fondation Ipsen, Boulogne Billancourt, France
Yves Christen