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Two Faces of Evil: Cancer and Neurodegeneration

  • Book
  • © 2011

Overview

Editors:
  1. Thomas Curran

    1. , Department of Pathology and Laboratory M, The Children's Hospital of Philadelphia, Philadelphia, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Yves Christen

    1. Fondation IPSEN, Boulogne-Billancourt Cedex, France

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    You can also search for this editor in PubMed   Google Scholar

  • Several new concepts were shared that will stimulate future research and perhaps contribute to better therapies for cancer patients as well as those struggling with the ravages of neurodegeneration.
  • Includes supplementary material: sn.pub/extras

Part of the book series: Research and Perspectives in Alzheimer's Disease (ALZHEIMER)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Updating the Mammalian Cell Cycle: The Role of Interphase Cdks in Tissue Homeostasis and Cancer

    • Mariano Barbacid
    Pages 1-16

  3. The Role of Cdk5 as a Cell Cycle Suppressor in Post-mitotic Neurons

    • Karl Herrup
    Pages 17-25

  4. Actin-SRF Signaling in the Developing and Mature Murine Brain

    • Alfred Nordheim, Bernd Knöll
    Pages 27-39

  5. The E3 Ubiquitin Ligase Ube3A Regulates Synaptic Function Through the Ubiquitination of Arc

    • Eric C. Griffith, Paul L. Greer, Michael E. Greenberg
    Pages 41-56

  6. Targeting Children’s Brain Tumors: Development of Hedgehog Pathway Inhibitors for Medulloblastoma

    • Tom Curran
    Pages 57-71

  7. Primary Cilia as Switches in Brain Development and Cancer

    • Young-Goo Han, Arturo Alvarez-Buylla
    Pages 73-82

  8. Nervous System Aging, Degeneration, and the p53 Family

    • Freda D. Miller, David R. Kaplan
    Pages 83-93

  9. p53, a Molecular Bridge Between Alzheimer’s Disease Pathology and Cancers?

    • Frédéric Checler, Julie Dunys, Raphaëlle Pardossi-Piquard, Cristine Alves da Costa
    Pages 95-101

  10. RNA regulation in Neurodegeneration and Cancer

    • Robert B. Darnell
    Pages 103-111

  11. Bridging Environment and DNA: Activity-Induced Epigenetic Modification in the Adult Brain

    • Dengke K. Ma, Junjie U. Guo, Guo-li Ming, Hongjun Song
    Pages 113-123

  12. Intrinsic Brain Signaling Pathways: Targets of Neuron Degeneration

    • Harry T. Orr
    Pages 125-131

  13. The miRNA System: Bifurcation Points of Cancer and Neurodegeneration

    • Kenneth S. Kosik, Pierre Neveu, Sourav Banerjee
    Pages 133-142

  14. Molecular Mechanisms for the Initiation and Maintenance of Long-Term Memory Storage

    • Sathyanarayanan Puthanveettil, Eric Kandel
    Pages 143-160

  15. Back Matter

    Pages 161-163
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Keywords

About this book

Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes

Reviews

From the reviews:

“The authors look at the etiology and molecular pathophysiology of several genes involved in cellular demise and cell proliferation. … The book is going to be of interest to cell biologists primarily and anyone with an interest in cancer or neurodegeneration.” (Joseph J. Grenier, Amazon.com, September, 2013)

Editors and Affiliations

  • , Department of Pathology and Laboratory M, The Children's Hospital of Philadelphia, Philadelphia, USA

    Thomas Curran

  • Fondation IPSEN, Boulogne-Billancourt Cedex, France

    Yves Christen

Bibliographic Information

  • Book Title: Two Faces of Evil: Cancer and Neurodegeneration

  • Editors: Thomas Curran, Yves Christen

  • Series Title: Research and Perspectives in Alzheimer's Disease

  • DOI: https://doi.org/10.1007/978-3-642-16602-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2011

  • Hardcover ISBN: 978-3-642-16601-3Published: 07 April 2011

  • Softcover ISBN: 978-3-642-26771-0Published: 29 May 2013

  • eBook ISBN: 978-3-642-16602-0Published: 16 December 2010

  • Series ISSN: 0945-6066

  • Series E-ISSN: 2196-310X

  • Edition Number: 1

  • Number of Pages: XIV, 166

  • Topics: Neurosciences, Cancer Research

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