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Intracellular Traffic and Neurodegenerative Disorders

  • Book
  • © 2009

Overview

Editors:
  1. Peter H. St. George-Hyslop

    1. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada

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  2. William C. C. Mobley

    1. Department of Neurology, Standford University School of Medicine, Standford, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Yves Christen

    1. Fondation IPSEN Pour la Recherche Thérapeutique, Boulogne Billancourt, Cedex - France

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Research and Perspectives in Alzheimer's Disease (ALZHEIMER)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Amyloid Precursor Protein Sorting and Processing: Transmitters, Hormones, and Protein Phosphorylation Mechanisms

    • Sam Gandy, Odete da Cruz e Silva, Edgar da Cruz e Silva, Toshiharu Suzuki, Michelle Ehrlich, Scott Small
    Pages 1-9

  3. Intramembrane Proteolysis by γ-Secretase and Signal Peptide Peptidases

    • Regina Fluhrer, Christian Haass
    Pages 11-26

  4. Axonal Transport and Neurodegenerative Disease

    • Erika L. F. Holzbaur
    Pages 27-39

  5. Simple Cellular Solutions to Complex Problems

    • Susan Lindquist, Karen L. Allendoerfer
    Pages 41-57

  6. Tau and Intracellular Transport in Neurons

    • E.-M. Mandelkow, E. Thies, S. Konzack, E. Mandelkow
    Pages 59-70

  7. Signaling Between Synapse and Nucleus During Synaptic Plasticity

    • Kwok-On Lai, Dan Wang, Kelsey C. Martin
    Pages 71-85

  8. Axonal Transport of Neurotrophic Signals: An Achilles' Heel for Neurodegeneration?

    • Ahmad Salehi, Chengbiao Wu, Ke Zhan, William C. Mobley
    Pages 87-101

  9. Membrane Trafficking and Targeting in Alzheimer's Disease

    • Lawrence Rajendran, Kai Simons
    Pages 103-113

  10. Huntington's Disease: Function and Dysfunction of Huntingtin in Axonal Transport

    • Frédéric Saudou, Sandrine Humbert
    Pages 115-123

  11. The Role of Retromer in Neurodegenerative Disease

    • Claire F. Skinner, Matthew N.J. Seaman
    Pages 125-140

  12. Regulation of Endocytic Trafficking of Receptors and Transporters by Ubiquitination: Possible Role in Neurodegenerative Disease

    • Alexander Sorkin
    Pages 141-155

  13. The Sortilin-Related Receptor SORL1 is Functionally and Genetically Associated with Alzheimer's Disease

    • Ekaterina Rogaeva, Yan Meng, Joseph H. Lee, Richard Mayeux, Lindsay A. Farrer, Peter St George-Hyslop
    Pages 157-165

  14. Regulation of Transport and Processing of Amyloid Precursor Protein by the Sorting Receptor SORLA

    • Thomas E. Willnow, Michael Rohe, Anne-Sophie Carlo, Vanessa Schmidt
    Pages 167-179

  15. Back Matter

    Pages 181-184
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Keywords

About this book

This book explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. Recent findings point to faulty trafficking as contributing to the dysfunction and degeneration of neurons and neural circuits. Increasingly, research is targeting the mechanisms responsible and means to address them therapeutically. Many adult onset neurodegenerative diseases appear to arise from the accumulation of misfolded, neurotoxic peptides. This book investigates the ways in which sub-cellular trafficking pathways play a role both in the pathological accumulation of these misfolded proteins and in attempts to clear them. Because subcellular protein trafficking has an important role in the biology of neuronal function and survival, this also addresses how trophic factors maintain cell: cell interactions and how the underlying mechanisms may be compromised in neurodegenerative diseases. Examples where the use of such trophic factors may provide a way to modify neurodegenerative diseases are investigated.

Reviews

From the reviews:

“This monograph is an up to date account of the abnormalities in axonal transport of proteins and molecules in neurons in the aging and diseased brain. … This book is meant for neuropathologists, neurologists, and advanced graduate students in the Neurosciences. I can recommend it for these professionals without hesitation.” (Joseph J. Grenier, Amazon.com, November, 2013)

Editors and Affiliations

  • Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada

    Peter H. St. George-Hyslop

  • Department of Neurology, Standford University School of Medicine, Standford, USA

    William C. C. Mobley

  • Fondation IPSEN Pour la Recherche Thérapeutique, Boulogne Billancourt, Cedex - France

    Yves Christen

Bibliographic Information

  • Book Title: Intracellular Traffic and Neurodegenerative Disorders

  • Editors: Peter H. St. George-Hyslop, William C. C. Mobley, Yves Christen

  • Series Title: Research and Perspectives in Alzheimer's Disease

  • DOI: https://doi.org/10.1007/978-3-540-87941-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2009

  • Hardcover ISBN: 978-3-540-87940-4Published: 10 December 2008

  • Softcover ISBN: 978-3-642-09972-4Published: 25 November 2010

  • eBook ISBN: 978-3-540-87941-1Published: 03 February 2009

  • Series ISSN: 0945-6066

  • Series E-ISSN: 2196-310X

  • Edition Number: 1

  • Number of Pages: XIV, 184

  • Number of Illustrations: 11 b/w illustrations, 25 illustrations in colour

  • Topics: Neurosciences

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