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Biomedical Sciences - Neuroscience | Orphan G Protein-Coupled Receptors and Novel Neuropeptides

Orphan G Protein-Coupled Receptors and Novel Neuropeptides

Civelli, Olivier, Zhou, Qun-Yong (Eds.)

2008, XV, 259 p.

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  • Comprehensive overview on GPCRs and the novel neuropeptides discovered with their help
  • Most authors are the original discoverers of the respective novel neuropeptides
  • First book to also describe the functional significance of novel neuropeptides

Over the last decade it has been shown that orphan G protein-coupled receptors (GPCRs) can be used as targets to discover novel neuropeptides. A dozen neuropeptides have been identified through this approach. Each of these neuropeptides has opened new doors for our understanding of fundamental physiological or behavioral responses. For example the orexins, MCH and ghrelin carry fundamental roles in regulating food intake while neuropeptide S, neuromedin S, the prokineticins and the orexins are major players in modulating sleep and circadian rhythms.

The chapters of this book review the latest research in the field, most of them are written by the original discoverers of the respective novel neuropeptide. Emphasis is set not only on their discovery but also on their functional significance. Since many of these neuropeptides are part of drug discovery programs, this book impacts academic as well as pharmaceutical research.

Content Level » Research

Keywords » G protein-coupled receptors - Orphan GPCR - PCR - anatomy - drug discovery - homeostasis - neuropeptides - physiology - prolactin

Related subjects » Cell Biology - Internal Medicine - Neuroscience - Pharmacology & Toxicology

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