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Biomedical Sciences - Neuroscience | The Pineal Organ, Its Hormone Melatonin, and the Photoneuroendocrine System

The Pineal Organ, Its Hormone Melatonin, and the Photoneuroendocrine System

Korf, Werner, Schomerus, Christof, Stehle, Jörg H.

1998, X, 100 pp. 31 figs.

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  • About this book

This book offers a synoptic view of comparative anatomical, ultrastructural, cell and molecular biological investigations of the pineal organ. It considers morphological, immunocytochemical and functional features of pineal photoreceptors and neuroendocrine pinealocytes as well as the afferent and efferent innervation of the pineal organ. Special emphasis is placed on receptor mechanisms, second messenger systems (Ca2+ and cyclic AMP), transcription factors (e.g. cyclic AMP response element binding protein, CREB, and inducible cyclic AMP early repressor, ICER) and their roles for regulation of melatonin biosynthesis. Finally, the action, targets and receptors of melatonin are dealt with. The data presented stress the functional significance of the pineal organ and its hormoe melatonin as important components of the photoneuroendocrine system which allows man and animals to measure and keep the time. They also prove the pineal organ as a very suitable model to study signal transduction mechanisms in both photoreceptors and neuroendocrine cells by means of a variety of modern techniques.

Content Level » Research

Keywords » Regulation - anatomy - biosynthesis - cell biology - melatonin biosynthesis - molecular biology - pineal photoreceptors - pineal transcription factors - transcription

Related subjects » Animal Sciences - Cell Biology - Neuroscience

Table of contents 

Introduction.-Phylogenetic Development and Gross Anatomy of the Pineal Complex.-Pineal Cell Biology and Innervation.-General Aspects.-Cell Biology of True Pineal Photoreceptors, Modified Pineal Photoreceptors and Pinealocytes of the Mammalian Type.-Central Innervation of the Pineal Organ.-Sypathetic (Noradrenergic) Innervation of the Pineal.-Parasympathetic Innervation of the Pineal Organ.-Receptor Mechanisms and Second Messenger Systems Involved in the Regulation of the Melatonin Biosynthesis.-General Aspects.-Anamniotes.-Birds.-Mammals.-Pineal Transcription Factors and Their Possible Roles for the Regulation of the Melatonin Biosynthesis.-Action, Targets and Receptors of Melatonin.-Summary.-References

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