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Neuroanatomy and Pathology of Sporadic Alzheimer's Disease

  • Book
  • © 2015

Overview

Authors:
  1. Heiko Braak

    1. Zentrum f. Biomed. Forschung AG, Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany

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  2. Kelly Del Tredici

    1. Zentrum f. Biomed. Forschung AG, Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany

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    You can also search for this author in PubMed   Google Scholar

  • Written by experts in the field of Alzheimer's disease
  • Provides excellent anatomical and pathological basis for researchers working with experimental and molecular-biological aspects of Alzheimer's disease
  • Provides an overview on all pathological changes in the central nervous system after the onset of Alzheimer's disease
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Anatomy, Embryology and Cell Biology (ADVSANAT, volume 215)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xi
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  2. Prologue

    • Heiko Braak, Kelly Del Tredici
    Pages 1-2

  3. Introduction

    • Heiko Braak, Kelly Del Tredici
    Pages 3-14

  4. Basic Organization of Non-thalamic Nuclei with Diffuse Cortical Projections

    • Heiko Braak, Kelly Del Tredici
    Pages 15-19

  5. Microtubules and the Protein Tau

    • Heiko Braak, Kelly Del Tredici
    Pages 21-24

  6. Early Presymptomatic Stages

    • Heiko Braak, Kelly Del Tredici
    Pages 25-36

  7. Basic Organization of Territories That Become Sequentially Involved After Initial Involvement of Brainstem Nuclei with Diffuse Projections

    • Heiko Braak, Kelly Del Tredici
    Pages 37-55

  8. The Pattern of Cortical Lesions in Preclinical Stages

    • Heiko Braak, Kelly Del Tredici
    Pages 57-73

  9. Alzheimer-Associated Pathology in the Extracellular Space

    • Heiko Braak, Kelly Del Tredici
    Pages 75-93

  10. The Pattern of Lesions During the Transition to the Symptomatic Phase and in Fully Developed Alzheimer’s Disease

    • Heiko Braak, Kelly Del Tredici
    Pages 95-130

  11. Final Considerations

    • Heiko Braak, Kelly Del Tredici
    Pages 131-133

  12. Technical Addendum

    • Heiko Braak, Kelly Del Tredici
    Pages 135-139

  13. Back Matter

    Pages 141-162
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Keywords

About this book

As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail

Authors and Affiliations

  • Zentrum f. Biomed. Forschung AG, Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany

    Heiko Braak, Kelly Del Tredici

Bibliographic Information

  • Book Title: Neuroanatomy and Pathology of Sporadic Alzheimer's Disease

  • Authors: Heiko Braak, Kelly Del Tredici

  • Series Title: Advances in Anatomy, Embryology and Cell Biology

  • DOI: https://doi.org/10.1007/978-3-319-12679-1

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2015

  • Softcover ISBN: 978-3-319-12678-4Published: 23 December 2014

  • eBook ISBN: 978-3-319-12679-1Published: 11 December 2014

  • Series ISSN: 0301-5556

  • Series E-ISSN: 2192-7065

  • Edition Number: 1

  • Number of Pages: XI, 162

  • Number of Illustrations: 4 b/w illustrations, 44 illustrations in colour

  • Topics: Neurosciences, Pathology, Geriatrics/Gerontology

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