Overview
- The book presents C. elegans as model organism for the development of the nervous system translation
- Discusses various disorders that are associated with improper wiring of the nervous system
- Gives an overview on various interactomes involved in DV and AP guidance, their mechanism of action, subcellular localization and functional role
- Includes supplementary material: sn.pub/extras
Part of the book series: SpringerBriefs in Neuroscience (BRIEFSNEUROSCI, volume 0)
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Table of contents (5 chapters)
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Front Matter
Keywords
About this book
This book gives an overview of various interactomes involved in dorsal ventral (DV) and anterior posterior (AP) guidance, their mechanisms of action, subcellular localizations, and functional roles. It will provide readers a better understanding of the development of the nervous system, which in turn will help to find cures to various neural and other disorders.
In nematodes there are two types of guidance systems, including DV and AP guidance. The signaling process that guides the growth cones along the DV axis has remained intact in both vertebrates and invertebrates. The adaptor protein UNC-53 appears to play a part in migration along the AP axis in both worms and their human homologs. “Neuron Navigators” (NAV) are also involved in nervous system development
Authors and Affiliations
Bibliographic Information
Book Title: The UNC-53-mediated Interactome
Book Subtitle: Analysis of its Role in the Generation of the C. elegans Connectome
Authors: Amita Pandey, Girdhar K. Pandey
Series Title: SpringerBriefs in Neuroscience
DOI: https://doi.org/10.1007/978-3-319-07827-4
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Author(s) 2014
Softcover ISBN: 978-3-319-07826-7Published: 23 July 2014
eBook ISBN: 978-3-319-07827-4Published: 05 July 2014
Series ISSN: 2191-558X
Series E-ISSN: 2191-5598
Edition Number: 1
Number of Pages: VI, 87
Number of Illustrations: 1 b/w illustrations, 14 illustrations in colour
Topics: Neurosciences, Neurobiology, Neurology