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Biomedical Sciences - Neuroscience | The UNC-53-mediated Interactome - Analysis of its Role in the Generation of the C. elegans Connectome

The UNC-53-mediated Interactome

Analysis of its Role in the Generation of the C. elegans Connectome

Pandey, Amita, Pandey, Girdhar K.

2014, VI, 87 p. 15 illus., 14 illus. in color.

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  • The book presents C. elegans as model organism for the development of the nervous system translation
  • Discusses various disorders that are associated with improper wiring of the nervous system
  • Gives an overview on various interactomes involved in DV and AP guidance, their mechanism of action, subcellular localization and functional role

This book gives an overview of various interactomes involved in dorsal ventral (DV) and anterior posterior (AP) guidance, their mechanisms of action, subcellular localizations, and functional roles. It will provide readers a better understanding of the development of the nervous system, which in turn will help to find cures to various neural and other disorders.​

In nematodes there are two types of guidance systems, including DV and AP guidance. The signaling process that guides the growth cones along the DV axis has remained intact in both vertebrates and invertebrates. The adaptor protein UNC-53 appears to play a part in migration along the AP axis in both worms and their human homologs. “Neuron Navigators” (NAV) are also involved in nervous system development 

Content Level » Research

Keywords » C. elegans interactome - axon and cell migragion - connectome - develoment of the nervous system - downstream signaling pathways - neural disorders

Related subjects » Neurology - Neuroscience

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