Overview
- Focus on quantitative structure-activity relationship of MMP inhibitors
- Contains an overview of endogenous tissue inhibitors of MMPs and their biological relevance
- Written by experts in the field
- Includes supplementary material: sn.pub/extras
Part of the book series: Experientia Supplementum (EXS, volume 103)
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Table of contents (7 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results in tissue degradation, producing a wide array of disease processes such as rheumatoid arthritis, osteoarthritis, tumor growth and metastasis, multiple sclerosis, congestive heart failure, and others. Thus MMP inhibitors are candidates for therapeutic agents to combat a number of diseases.
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The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases. The articles focus specifically on structure-activity relationships of all classes of compounds and on their modes of action and specificity of binding with the receptors based on experimental and theoretical studies. These studies constitute a valuable asset for all those involved in drug development.
Editors and Affiliations
Bibliographic Information
Book Title: Matrix Metalloproteinase Inhibitors
Book Subtitle: Specificity of Binding and Structure-Activity Relationships
Editors: Satya Prakash Gupta
Series Title: Experientia Supplementum
DOI: https://doi.org/10.1007/978-3-0348-0364-9
Publisher: Springer Basel
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Basel AG 2012
Hardcover ISBN: 978-3-0348-0363-2Published: 07 April 2012
Softcover ISBN: 978-3-0348-0764-7Published: 09 May 2014
eBook ISBN: 978-3-0348-0364-9Published: 05 April 2012
Series ISSN: 1664-431X
Series E-ISSN: 2504-3692
Edition Number: 1
Number of Pages: X, 286
Topics: Neurosciences