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Biomedical Sciences - Neuroscience | Microelectrode Biosensors

Microelectrode Biosensors

Series: Neuromethods, Vol. 80

Marinesco, Stéphane, Dale, Nicholas (Eds.)

2013, XV, 387 p. 111 illus., 45 illus. in color.

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  • Covers, in great detail, electrochemical biosensor technology as applied to the neurosciences
  • Explores the great progress in this field with in-depth methodologies
  • Features tips from the experts, included to ensure optimal results

For molecules that are not directly electroactive, it is necessary to modify a microelectrode by grafting polymeric or enzymatic membranes capable of translating a local concentration into an electrical current, which is a concept referred to as biosensing. In Microelectrode Biosensors, experts in the field cover the topic of electrochemical biosensor technology as applied to the neurosciences.  The volume opens with a section addressing the specific issue of manufacturing biosensors that can be implanted in the central nervous system for neurotransmitter detection, and it then continues with sections on recent studies where biosensors have made a difference in bringing a new level of understanding of signaling mechanisms in neuroscience as well as recent developments in biosensor technology that have not yet been applied to implantable microelectrodes but may have great potential. Written for the Neuromethods series, this work contains the kind of detailed descriptions and implementation advice necessary to achieve successful results.

 

Focused and cutting-edge, Microelectrode Biosensors serves to inspire the wider neuroscience and physiology community to adopt these powerful methods in their own applications in order to move the field forward with the widespread advances that will most likely flow from the adoption of biosensing as part of the standard laboratory toolkit.

Content Level » Professional/practitioner

Keywords » Biosensing - Electrochemical biosensor - Implantable microelectrodes - Neurotransmitters - Signaling mechanisms

Related subjects » Neuroscience

Table of contents 

Part I: Designs, Principles, and Methods

 

1. Microelectrode Designs for Oxidase-Based Biosensors

            Stéphane Marinesco and Olivier Frey

 

2. Microelectrode Array Fabrication and Optimization for Selective Neurochemical Detection

            Kevin N. Hascup, Erin R. Hascup, O. Meagan Littrell, Jason M. Hinzman, Catherine E. Werner, Verda A. Davis, Jason J. Burmeister, Francois Pomerleau, Jorge E. Quintero, Peter Huettl, and Greg A. Gerhardt

 

3. The Advantage of Microelectrode Technologies for Measurement in Delicate Biological Environments Such as Brain Tissue

            Andrea Jaquins-Gerstl and Adrian C. Michael

 

4. Hexacyanoferrates as Mediators for Microelectrode Biosensors

            Faming Tian and Nicholas Dale

 

5. Enzyme Immobilization on Microelectrode Biosensors

            Natalia Vasylieva and Stéphane Marinesco

 

6. Characterization of Polymer–Enzyme Composite Biosensors for Brain Monitoring In Vivo

            Robert D. O’Neill

 

Part II: Case Studies

 

7. Monitoring Extracellular Glutamate in the Brain by Microdialysis and Microsensors

            Si Qin, Miranda (van der Zeyden) Evering, Ngabi Wahono, Thomas I.F.H. Cremers, and Ben H.C. Westerink

 

8. Sub-Second Measurements of Glutamate and Other Neurotransmitter Signaling Using Enzyme-Based Ceramic Microelectrode Arrays

            Erin R. Hascup, Kevin N. Hascup, Pooja M. Talauliker, David A. Price, Francois Pomerleau, Jorge E. Quintero, Peter Huettl, Alain Gratton, Ingrid Strömberg, and Greg A. Gerhardt

 

9. Regulation of Extracellular Concentrations of D-Serine in the Central Nervous System Revealed by D-Amino Acid Oxidase Microelectrode Biosensors

            Pierre Pernot, Caroline Maucler, and Stéphane Marinesco

 

10. Measurement of Purine Release with Microelectrode Biosensors

            Nicholas Dale

 

11. Glucose and Lactate Monitoring Across the Rat Sleep-Wake Cycle

            Raymond Cespuglio, Larissa Netchiporouk, and Nataliya Shram

 

12. Forebrain Cholinergic Systems and Cognition: New Insights Based on Rapid Detection of Choline Spikes Using Enzyme-Based Biosensors

            Vinay Parikh and Martin Sarter

 

Part III: The Future?

 

13. Carbon Nanotubes-Based Microelectrode (Bio)sensors

            Paloma Yáñez-Sedeño, Lourdes Agüí, and José M. Pingarrón

 

14. Label-Free Affinity Biosensors Based on Electrochemical Impedance Spectroscopy

            Nicole Jaffrezic-Renault

 

15. Aptamer-Based Electrochemical Biosensors for the Detection of Small Molecules and Plasma Proteins

            Cassie Ho and Hua-Zhong Yu

 

16. Electrochemiluminescent Biosensors: Neuroscience Applications

            Robert J. Forster and Tia E. Keyes

 

17. Molecularly Imprinted Polymers: Promising Advanced Materials for In Vivo Sensing

            Samir Akhtar, Dan Fei, Farhan Mirza, Sergey Piletsky, Shenqi Wang, and Yi Ge

            Si Qin, Miranda (van der Zeyden) Evering, Ngabi Wahono, Thomas I.F.H. Cremers, and Ben H.C. Westerink

 

8. Sub-Second Measurements of Glutamate and Other Neurotransmitter Signaling Using Enzyme-Based Ceramic Microelectrode Arrays

            Erin R. Hascup, Kevin N. Hascup, Pooja M. Talauliker, David A. Price, Francois Pomerleau, Jorge E. Quintero, Peter Huettl, Alain Gratton, Ingrid Strömberg, and Greg A. Gerhardt

 

9. Regulation of Extracellular Concentrations of D-Serine in the Central Nervous System Revealed by D-Amino Acid Oxidase Microelectrode Biosensors

            Pierre Pernot, Caroline Maucler, and Stéphane Marinesco

 

10. Measurement of Purine Release with Microelectrode Biosensors

            Nicholas Dale

 

11. Glucose and Lactate Monitoring Across the Rat Sleep-Wake Cycle

            Raymond Cespuglio, Larissa Netchiporouk, and Nataliya Shram

 

12. Forebrain Cholinergic Systems and Cognition: New Insights Based on Rapid Detection of Choline Spikes Using Enzyme-Based Biosensors

            Vinay Parikh and Martin Sarter

 

Part III: The Future?

 

13. Carbon Nanotubes-Based Microelectrode (Bio)sensors

            Paloma Yáñez-Sedeño, Lourdes Agüí, and José M. Pingarrón

 

14. Label-Free Affinity Biosensors Based on Electrochemical Impedance Spectroscopy

            Nicole Jaffrezic-Renault

 

15. Aptamer-Based Electrochemical Biosensors for the Detection of Small Molecules and Plasma Proteins

            Cassie Ho and Hua-Zhong Yu

 

16. Electrochemiluminescent Biosensors: Neuroscience Applications

            Robert J. Forster and Tia E. Keyes

 

17. Molecularly Imprinted Polymers: Promising Advanced Materials for In Vivo Sensing

            Samir Akhtar, Dan Fei, Farhan Mirza, Sergey Piletsky, Shenqi Wang, and Yi Ge

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