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Biomedical Sciences - Neuroscience | Animal Models of Brain Tumors

Animal Models of Brain Tumors

Series: Neuromethods, Vol. 77

Martínez Murillo, Ricardo, Martínez, Alfredo (Eds.)

2013, XIII, 391 p. 66 illus., 43 illus. in color.

A product of Humana Press
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  • Brings together recent discoveries and developments in brain tumor cellular and molecular mechanisms
  • Includes detailed protocols that are ready for the lab
  • Features expert tips and key implementation advice to ensure successful results

Although the available models, whether at the cellular, tissue, or animal level, do not exactly represent the biology of human brain tumors, animal models can offer significant insights into these tumors, providing a better understanding of biological mechanisms underlying tumor generation, growth, angiogenesis, invasion, and metastasis.  Animal Models of Brain Tumors brings together developments and discoveries in “in vivo” experimental tumor research that have provided advances in our understanding of the cellular and molecular mechanisms involved in the generation, progression, and clinical outcome of brain neoplasms. Broken into convenient sections, this thorough volume includes topics such as animal model insights into human brain neoplasms, the cellular, molecular, and genetic basis of brain tumors,  therapies in the treatment of malignant glioma, as well as imaging technologies in animal tumor models, i.e. measuring brain tumor growth and metabolism.  Written for the popular Neuromethods series, chapters include the kind of detailed description and implementation advice that is essential for achieving successful results.


Authoritative and cutting-edge, Animal Models of Brain Tumors provides the key methods needed to validate, compare, and contrast the animal model with its proposed human counterpart and further the understanding of our own serious ailments.

Content Level » Professional/practitioner

Keywords » Brain neoplasms - Experimental neuro-oncology - Imaging technologies - Malignant glioma therapies - Oncogenesis - Tumor biology

Related subjects » Animal Sciences - Neurology - Neuroscience

Table of contents 

Part I: Introduction

Brain Tumor Models to Predict Clinical Outcome: Like the Phoenix?

            Lois A. Lampson


Animal Models in Cancer Research: Assessment of Severity and the Application of Humane Endpoints

            José M. Orellana-Muriana


Part II: Animal Models Offer Insights into Human Brain Neoplasms


The VM Mouse Model of Glioblastoma Multiforme

            Thomas N. Seyfried, Laura M. Shelton, and Leanne C. Huysentruyt


Oligodendroglioma Models

            Nanna Lindberg and Lene Uhrbom


Medulloblastoma Model

            Jasmine Lau and William A. Weiss


Learning about Retinoblastoma from Mouse Models that Missed

            David Cobrinik


Ependymoma Models

            Jesús Vaquero and Mercedes Zurita


Meningioma Models

            Jessica Rainey and Randy L. Jensen


Pituitary Models

            Walavan Sivakumar and William T. Couldwell


Growth Regulation of Nervous System Tumors: Models for Assessment of Angiogenesis in Brain Tumors

            Kelly Burrell, Elena Bogdanovic, Shahrzad Jalali, Gelareh Zadeh, and Abhijit Guha


Part III: Cellular, Molecular, and Genetic Basis of Brain Tumors: Data from Animal Models


Using Genetically-Engineered Mouse Models to Understand Low-Grade Glioma Development and Growth in Children

            Aparna Kaul, Ibrahim Hussain, and David H. Gutmann


EGFR and Tumor–Suppressor Function in Brain Cancer Development

            Julie Lessard and Al Charest


Part IV: Therapies in the Treatment of Malignant Glioma: Data from Animal Models


Rodent Glioma Models: Intracranial Stereotactic Allografts and Xenografts

            Hikmat Assi, Marianela Candolfi, Pedro R. Lowenstein, and Maria G. Castro


Immunotherapy of High-Grade Gliomas: Preclinical In Vivo Experiments in Animal Models

            Kristen A. Batich, Bryan D. Choi, and Duane A. Mitchell


Assessing Mechanisms of Glioblastoma Invasion

            Stephen M. Robbins and Donna L. Senger


Part V: Imaging Technologies in Animal Tumor Models: Measuring Brain Tumor Growth and Metabolism


Positron Emission Tomography (PET)-Based Molecular Imaging

            Yannic Waerzeggers, Thomas Viel, Sonja Schäfers, Stefan Wagner, Andreas Faust, Burkhard Riemann, Klaus Kopka, Otmar Schober, Klaus Schäfers, and Andreas H. Jacobs


In Vivo Magnetic Resonance Spectroscopic Imaging (MRSI) and Ex Vivo Quantitative Neuropathology by High Resolution Magic Angle Spinning Proton Magnetic Resonance Spectroscopy (HRMAS)

            Rui V. Simões, Ana Paula Candiota, Margarida Julià-Sapé, and Carles Arús


Single Photon Emission Computed Tomography (SPECT) in Small Animal CNS Research

            André Constantinesco, Christian Goetz, and Philippe Choquet

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