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Biomedical Sciences - Neuroscience | Animal Models of Acute Neurological Injuries II - Injury and Mechanistic Assessments, Volume 1

Animal Models of Acute Neurological Injuries II

Injury and Mechanistic Assessments, Volume 1

Chen, J., Xu, X.-M., Xu, Z.C., Zhang, J.H. (Eds.)

2012, XVIII, 724 p. 167 illus., 125 illus. in color.

A product of Humana Press
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  • Presents the material in a disease/disorder oriented manner for convenient reference
  • Offers both recommended, established techniques and alternative methods that have their own special utility
  • Features key tips and implementation advice to ensure successful results

The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries.  Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments aims to collect chapters on assessing these disorders from cells and molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system.  Volume 1 examines general assessments in morphology, physiology, biochemistry and molecular biology, neurobehavior, and neuroimaging, as well as extensive sections on subarachnoid hemorrhage, cerebral vasospasm, and intracerebral hemorrhage.  Designed to provide both expert guidance and step-by-step procedures, chapters serve to increase understanding in what, why, when, where, and how a particular assessment is used.


Accessible and essential, Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments will be useful for trainees or beginners in their assessments of acute neurological injuries, for experienced scientists from other research fields who are interested in either switching fields or exploring new opportunities, and for established scientists within the field who wish to employ new assessments.

Content Level » Professional/practitioner

Keywords » Acute neurological injury - Animal models - Cerebral vasospasm - General assessments - Intracerebral hemorrhage - Morphological assessments - Neurobehavior - Neuroimaging - Subarachnoid hemorrhage

Related subjects » Animal Sciences - Neurology - Neuroscience

Table of contents 

Part I: General Morphological Assessments


1. Histopathological Assessments of Animal Models of Cerebral Ischemia

            Ami P. Raval and Bingren Hu


2. Assessment of Cell Death: Apoptosis, Necrosis, or In Between

            Tom Genetta, Ling Wei, and Shan Ping Yu


3. The Stereology and 3D Volume Analyses in Nervous Tissue

            Rabindra P. Singh, Li Shen, and Feng C. Zhou


4. Assessments of Reactive Astrogliosis Following CNS Injuries

            Candace L. Floyd


Part II: General Physiological Assessments


5. Physiological Assessment in Stroke Research

            Casey Lee Hall, Osama Mohamad, Shan Ping Yu, and Ling Wei


6. EEG, Evoked Potential (EP), and Extracellular Single Unit Recordings In Vivo

            Jie Wu


7. Intracellular Recording In Vivo and Patch-Clamp Recording on Brain Slices

            Ping Deng and Zao C. Xu


8. Electrophysiological Evaluation of Synaptic Plasticity in Injured CNS

            Xiaoming Jin


Part III: General Biochemical and Molecular Biological Assessments


9. Characterization of RNA

            Marcel P. Van der Brug, Mar Matarin, and Taura L. Barr


10. MicroRNA Expression Profiling of Rat Blood and Brain Tissues: TaqMan Real-Time PCR MicroRNA Assays

            Da-Zhi Liu, Bradley P. Ander, and Frank R. Sharp


11. Protein Analysis

            Anthony Kian-Fong Liou and Jun Chen


12. Application of Zymographic Methods to Study Matrix Enzymes Following Traumatic Brain Injury

            Lesley K. Harris, Raiford T. Black, Thomas M. Reeves, and Linda L. Phillips


Part IV: General Neurobehavioral Assessments


13. Rodent Behavioral Assessment in the Home Cage Using the SmartCageTM System

            Xinmin Simon Xie, Jingxi Zhang , Bende Zou, James Xie, Jidong Fang, Nurulain T. Zaveri, and Taline V. Khroyan


14. Assessments of Cognitive Function Following Traumatic Brain Injury

            Wendy M. Reid and Dong Sun


15. Assessment of Cognitive and Sensorimotor Deficits

            Richard E. Hartman


16. Emotional and Anxiety Assessments in CNS Disorders

            Zaorui Zhao and Junfang Wu


Part V: General Neuroimaging Assessments


17. Neuroimaging Assessment of Traumatic Brain Injury

            Janna L. Harris and William M. Brooks


18. Imaging of Myelin by Coherent Anti-Stokes Raman Scattering Microscopy

            Ji-Xin Cheng


Part VI: Subarachnoid Hemorrhage


19. Grading Scales for Subarachnoid Hemorrhage

            Andrew Losiniecki and Mario Zuccarello


20. Acute Physiologic and Morphologic Assessment Following Subarachnoid Hemorrhage

            Vincent DiNapoli and Mario Zuccarello


21. Aneurysmal Subarachnoid Hemorrhage Grading in Animal Models

            Robert Ayer, Takashi Sugawara, and John H. Zhang


22. Physiological Assessments of Subarachnoid Hemorrhage

            Jens P. Dreier


23. Spreading Depolarization

            Clemens Reiffurth, Sergei A. Kirov, and Jens P. Dreier


24. Assessment of Neurovascular Coupling

            Cecilia Nicoletti, Nikolas Offenhauser, Devi Jorks, Sebastian Major, and Jens P. Dreier


25. Assessment of Global Ischemia

            Fatima A. Sehba and Joshua B. Bederson


26. Assessment of Microthromboembolism after Subarachnoid Hemorrhage

            Mervyn D.I. Vergouwen and R. Loch Macdonald


27. Intracranial Pressure Assessments

            Carla S. Jung and Andreas W. Unterberg


28. Assessment of Blood-Brain Barrier Breakdown

            Yoash Hassidim, Ofer Prager, Ilan Shelef, and Alon Friedman


29. Electrophysiology and Morris Water Maze to Assess Hippocampal Function after Experimental Subarachnoid Hemorrhage

            Asma Tariq and R. Loch Macdonald


30. Biochemical and Molecular Biological Assessments of Subarachnoid Hemorrhage

            Joseph F. Clark


31. Neurobehavioral Assessments of Subarachnoid Hemorrhage

            Hidenori Suzuki and John H. Zhang


32. Neuroimaging Assessment of Subarachnoid Hemorrhage

            Andre Obenaus and Sam Barnes


Part VII: Cerebral Vasospasm


33. Introduction to Problems of Post-Subarachnoid Hemorrhage Delayed Cerebral Vasospasm

            Ryszard M. Pluta


34. Morphological Assessments of Cerebral Vasospasm

            Hiroki Ohkuma


35. Vasospasm: Measurement of Diameter, Perimeter and Wall Thickness

            Mohammed Sabri and R. Loch Macdonald


36. Light Microscopic Assessment

            Akira Munakata, Norihito Shimamura, and Hiroki Ohkuma


37. Electron Microscopic Assessment

            Norihito Shimamura, Akira Munakata, and Hiroki Ohkuma


38. Morphological Assessment of Microcirculation

            Hiroki Ohkuma and Shigeharu Suzuki


39. Electrophysiological Assessment of Cerebral Vasospasm

            Jinglu Ai and R. Loch Macdonald


40. Cranial Window Assessments in Experimental aSAH in Mice

            Ulf C. Schneider, Etienne N. Atangana, and Peter Vajkoczy


41. Laser Speckle Contrast Analysis (LASCA) Imaging

            Nils Hecht, Ulf Schneider, Johannes Woitzik, and Peter Vajkoczy


42. Ion Channel Assessment

            Marcel Alexander Kamp, Hans-Jakob Steiger, and Daniel Hänggi


43. Biochemical Assessments of Cerebral Vasospasm: Measurement of cGMP, PKC, and PTK in Cerebral Arteries

            Masayo Koide and Shigeru Nishizawa


44. Assessment of Intracellular Calcium in Cerebral Artery Myocytes

            Matthew A. Nystoriak, Masayo Koide, and George C. Wellman


45. Neurobehavioral Assessments of Cerebral Vasospasm

            Ryszard M. Pluta, Boris Skopets, and Jerald D. Kralik


46. Neuroimaging Assessment of Cerebral Vasospasm

            Kaisorn L. Chaichana, Gustavo Pradilla, and Rafael J. Tamargo


Part VIII: Intracerebral Hemorrhage


47. Morphological Assessment of Intracerebral Hemorrhage

            Qing Xie, Guohua Xi, and Ya Hua


48. Immunological Response to Experimental Intracerebral Hemorrhage: Morphological Assessments

            Elena Titova and Andre Obenaus


49. Intracranial Pressure Assessment

            Yangdong He, Ya Hua, and Guohua Xi


50. Hemoglobin Measurements

            Yangdong He, Ya Hua, and Guohua Xi


51. Biochemical and Molecular Biological Assessments of Intracerebral Hemorrhage

            Jin-Yul Lee, Ya Hua, Richard F. Keep, and Guohua Xi


52. Neurobehavioral Assessments of Intracerebral Hemorrhage

            Tim Lekic and John H. Zhang


53. Corner Turning Test for Evaluation of Asymmetry after Intracerebral Hemorrhage in Rodents

            Tim Lekic, William Rolland, Anatol Manaenko, Nancy Fathali, and John H. Zhang


54. Forelimb Use Asymmetry Analysis of Vertical Exploratory Activity after Intracerebral Hemorrhage in Rats and Mice

            Tim Lekic, Anatol Manaenko, and William Rolland, and John H. Zhang


55. The Vibrissae-Elicited Forelimb Placing Test after Intracerebral Hemorrhage in Rodents

            Tim Lekic, William Rolland, Anatol Manaenko, Nancy Fathali, and John H. Zhang


56. Imaging of Hematoma and Perihematomal Edema in Experimental Intracerebral Hemorrhage

            Veit Rohde, Walter Schulz-Schäffer, and Timo Krings

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