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Photosensitive Molecules for Controlling Biological Function

  • Book
  • © 2011

Overview

Editors:
  1. James J. Chambers

    1. , Department of Chemistry, University of Massachusetts, Amherst, Amherst, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Richard H. Kramer

    1. , Dept. of Molecular and Cell Biology, University of California, Berkeley, Berkeley, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Captures the most current methods in precise and non-invasive exploration of neural function via light
  • Features extensive sections on natural photosensitive proteins, caged neurotransmitters, and small molecule photoswitches
  • Includes expert implementation advice crucial for getting optimal results in the lab
  • Includes supplementary material: sn.pub/extras

Part of the book series: Neuromethods (NM, volume 55)

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Table of contents (14 protocols)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Photoreactive Small Molecules for Affecting Biological Function

    1. Front Matter

      Pages 1-1
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    2. Introduction to Part I: Caged Neurotransmitters

      • James J. Chambers, Richard H. Kramer
      Pages 3-5

    3. Targeting and Excitation of Photoactivatable Molecules: Design Considerations for Neurophysiology Experiments

      • Eugene F. Civillico, J. Peter Rickgauer, Samuel S.-H. Wang
      Pages 7-37

    4. Are Caged Compounds Still Useful?

      • Graham C. R. Ellis-Davies
      Pages 39-56

    5. Chromophores for the Delivery of Bioactive Molecules with Two-Photon Excitation

      • Timothy M. Dore, Hunter C. Wilson
      Pages 57-92

  3. Imparting Light Sensitivity on Cells Using Photosensitive Proteins

    1. Front Matter

      Pages 93-93
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    2. Introduction to Part II: Natural Photosensitive Proteins

      • James J. Chambers, Richard H. Kramer
      Pages 95-97

    3. Light-Activated Ion Pumps and Channels for Temporally Precise Optical Control of Activity in Genetically Targeted Neurons

      • Brian Y. Chow, Xue Han, Jacob G. Bernstein, Patrick E. Monahan, Edward S. Boyden
      Pages 99-132

    4. Vertebrate and Invertebrate Rhodopsins: Light Control of G-Protein Signaling

      • Davina V. Gutierrez, Eugene Oh, Stefan Herlitze
      Pages 133-146

    5. Restoring Visual Function After Photoreceptor Degeneration: Ectopic Expression of Photosensitive Proteins in Retinal Neurons

      • Bin Lin, Richard H. Masland
      Pages 147-164

  4. Molecular Photoswitch Conjugates to Remotely Affect Activity

    1. Front Matter

      Pages 165-165
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    2. Introduction to Part III: Small Molecule Photoswitches

      • James J. Chambers, Richard H. Kramer
      Pages 167-169

    3. Photoswitch Design

      • Andrew A. Beharry, G. Andrew Woolley
      Pages 171-184

    4. Photoswitchable Voltage-Gated Ion Channels

      • Doris L. Fortin, Richard H. Kramer
      Pages 185-212

    5. Optical Manipulation of Protein Activity and Protein Interactions Using Caged Proteins and Optical Switch Protein Conjugates

      • Yuling Yan, Gerard Marriott
      Pages 213-231

    6. Structure-Based Design of Light-Controlled Proteins

      • Harald Janovjak, Ehud Y. Isacoff
      Pages 233-266

    7. Photoswitchable Ligand-Gated Ion Channels

      • Pau Gorostiza, Ehud Y. Isacoff
      Pages 267-285

  5. Back Matter

    Pages 287-297
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Keywords

About this book

The development of new photochemical tools, some synthesized by chemists and some provided by nature, is rapidly changing the way neurobiological research is performed in the modern laboratory.  In Photosensitive Molecules for Controlling Biological Function, expert researchers in the field examine the most cutting-edge tools currently available.  Divided into three sections, this detailed compendium features techniques involving natural photosensitive proteins, caged neurotransmitters, and small molecule photoswitches that bestow light sensitivity on ion channels and receptors.  Written for the Neuromethods series, this volume features the type of meticulous description and implementation advice that is crucial for getting optimal results in the lab.

 

Authoritative and practical, Photosensitive Molecules for Controlling Biological Function provides an unbiased comparison of the various photochemical tools currently available for controlling neuronal activity in order to aid scientists in the vital goal of choosing the right tools for the right job.

Editors and Affiliations

  • , Department of Chemistry, University of Massachusetts, Amherst, Amherst, USA

    James J. Chambers

  • , Dept. of Molecular and Cell Biology, University of California, Berkeley, Berkeley, USA

    Richard H. Kramer

Bibliographic Information

  • Book Title: Photosensitive Molecules for Controlling Biological Function

  • Editors: James J. Chambers, Richard H. Kramer

  • Series Title: Neuromethods

  • DOI: https://doi.org/10.1007/978-1-61779-031-7

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC 2011

  • Hardcover ISBN: 978-1-61779-030-0Published: 03 March 2011

  • Softcover ISBN: 978-1-4939-5728-6Published: 23 August 2016

  • eBook ISBN: 978-1-61779-031-7Published: 02 March 2011

  • Series ISSN: 0893-2336

  • Series E-ISSN: 1940-6045

  • Edition Number: 1

  • Number of Pages: XIV, 297

  • Topics: Neurosciences, Neurobiology, Neurochemistry

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