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Fills a gap in developmental books dealing with the normal prenatal mammalian brain by focusing on both the pre-natal and the peri-natal events that lead to brain damage
Discusses major topics in detail, like sexual dimorphism, epigenetic action of gonadal hormones, environmental "programming" effects, autism, developmental learning disorders, seizures, and the etiopathogenesis of epileptic syndromes in young humans
Also covers general aspects of postnatal and pediatric neurological disorders by offering definitions of innate aspects of the mammalian brain in regards to its development
This book charts the way forward through the field of mammalian brain development, in which the integration of biological function can occur at all levels between the gene and the organism itself. Mammalian Brain Development examines the traditional "nature versus nurture" argument in the spectrum of brain development, discussing in particular sex differences in spatial perception ability, phenotype plasticity, disorders of brain development, Blood-Brain and placental barriers, chromosome abnormalities, as well as the use of imaging techniques. Geared toward neuroscientists, neurologists, pediatricians, pediatric psychiatrists, and neuroimmunologists, this volume paves the way toward the realization that the development of an individual is fundamentally an interaction between its genes and environment.
Table of Contents: Sexual differentiation of the brain: genetic, hormonal, and trophic factors
Hugo F. Carrer; María J. Cambiasso
Life at the interface between a dynamic environment and a fixed genome: Epigenetic programming of stress responses by maternal behavior
Ian Weaver, PhD
Effects of early life seizures and anti-epileptic drug treatment on brain development in human models
Amy Brooks-Kayal, MD; Eric Marsh, MD, PhD
Prenatal development of the human blood-brain barrier
Luca Cucullo, PhD
Seizure propensity and brain development: a lesson from animal models
Annamaria Vezzani, PhD; Jana Veliskova, PhD; Astrid Nehlig, PhD
Seizures and antiepileptic drugs: does exposure alter normal brain development in animals models?
Solomon Moshe, MD; Libor Velisek, MD, PhD; Aristea Galanopoulou, MD, PhD
Overview of neural mechanisms of developmental disorders
Ayush Batra; Dr. Kathleen Franco; Erin Carlton
Drug permeation across the fetal maternal barriers
Chaitali Ghosh; Nicola Marchi, PhD
In vivo imaging of brain development: Technologies, models, applications, and impact on understanding the etiology of mental retardation
Vicko Gluncic, MD
Congenital, non-inheritable chromosomal abnormalities responsible for neurological disorders
Patrizia D'Adamo and Riccardo Bianchi, PhD