Skip to main content
SpringerLink
Log in

Gene Therapy for Neurological Disorders and Brain Tumors

  • Book
  • © 1998

Overview

Editors:
  1. E. Antonio Chiocca

    1. Molecular Neuro-Oncology, Neurosurgical Service, Massachussetts General Hospital, Harvard Medical School, Boston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Xandra O. Breakefield

    1. Neurogenetics Unit, Massachussetts General Hospital, Harvard Medical Center, Boston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Contemporary Neuroscience (CNEURO)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (21 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Vectors and Promoters

    1. Front Matter

      Pages 1-6
      Download chapter PDF

    2. Retrovirus Vectors and Regulatable Promoters

      • Steven A. Reeves
      Pages 7-38

    3. Characteristics of Adenovirus Vectors

      • Susanna Chiocca, Matt Cotten
      Pages 39-52

    4. HSV Recombinant Vectors

      • Paul A. Johnson
      Pages 53-62

    5. HSV-1 Amplicon

      • Cornel Fraefel, Xandra O. Breakefield, David R. Jacoby
      Pages 63-82

    6. AAV Vectors

      • Frances I. Smith, Thomas J. McCown
      Pages 83-92

    7. EBV Vectors

      • Jean-Michel H. Vos, Keith B. Quattrocchi, Brian J. Wendelburg
      Pages 93-112

    8. Lentiviral Vectors for Gene Delivery in the Nervous System

      • Didier Trono, Ulrike Blömer, Luigi Naldini
      Pages 113-120

    9. Promoters for Expression of Gene Products within Neurons and Glia

      • John W. Henson
      Pages 121-146

    10. Immune Response to Viral Vectors

      • Jason G. Smith, Stephen L. Eck
      Pages 147-157

  3. Neuro-Oncology

    1. Front Matter

      Pages 159-159
      Download chapter PDF

    2. Current Treatment Modalities for Brain Tumor

      • Stephen B. Tatter, Griffith R. Harsh IV
      Pages 161-189

    3. Experimental and Clinical Gene Therapies for Brain Tumors

      • E. Antonio Chiocca
      Pages 191-203

    4. Tumor Suppressor Gene Therapy for Brain Tumors

      • Candelaria Gomez-Manzano, Juan Fueyo, Athanassios P. Kyritsis, W. K. Alfred Yung
      Pages 205-229

    5. Cytokine-Based Gene Therapy for Brain Tumors

      • John H. Sampson, Darell D. Bigner, Glenn Dranoff
      Pages 231-294

    6. Delivery of Therapeutic Genes to Brain and Intracerebral Tumors

      • Leslie L. Muldoon, Robert A. Kroll, Michael A. Pagel, Simon Roman-Goldstein, Edward A. Neuwelt
      Pages 295-312

    7. Rat Brain Tumor Models and the Statistical Evaluation of Survival Data in Experimental Neuro-Oncology

      • Rolf F. Barth, Melvin L. Moeschberger
      Pages 313-337

  4. Neurological Diseases

    1. Front Matter

      Pages 339-343
      Download chapter PDF

    2. Gene Transfer for Adult CNS Regeneration and Aging

      • Marie-Claude Senut, Isabelle Aubert, Philip J. Horner, Fred H. Gage
      Pages 345-375
Back to top

Keywords

About this book

Leading gene therapy researchers and clinicians illuminate the field-from basic vector technology to current and future clinical applications in neurology. The authoritative contributors provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorder, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea. Readers will learn the current delivery methods for transgenes, will learn the characteristics of transgene delivery vectors, and come to understand the therapy for both neuro-oncologic and neurologic disorders.

Reviews

"a very interesting book. . .all 'gene therapy laboratories' and 'neuo-gene therapy laboratories' will be able to derive much intellectual nourishment and stimulation, practical tips, and predictions about the future from this truly challenging volume."-Human Genetics

Editors and Affiliations

  • Molecular Neuro-Oncology, Neurosurgical Service, Massachussetts General Hospital, Harvard Medical School, Boston, USA

    E. Antonio Chiocca

  • Neurogenetics Unit, Massachussetts General Hospital, Harvard Medical Center, Boston, USA

    Xandra O. Breakefield

Bibliographic Information

  • Book Title: Gene Therapy for Neurological Disorders and Brain Tumors

  • Editors: E. Antonio Chiocca, Xandra O. Breakefield

  • Series Title: Contemporary Neuroscience

  • DOI: https://doi.org/10.1007/978-1-59259-478-8

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1998

  • Hardcover ISBN: 978-0-89603-507-2Published: 23 October 1997

  • Softcover ISBN: 978-1-4757-5314-1Published: 20 March 2013

  • eBook ISBN: 978-1-59259-478-8Published: 23 October 1997

  • Edition Number: 1

  • Number of Pages: XI, 458

  • Topics: Neurosciences

Publish with us

Policies and ethics

Back to top

Search

Navigation