The Chemokine Receptors

1. Front Matter

   Pages i-xiii

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2. The Birth and Maturation of Chemokines and Their Receptors

   • Nicholas W. Lukacs, Jeffrey K. Harrison

   Pages 1-8

3. The Structural Biology of Chemokines

   • Elias Lolis, James W. Murphy

   Pages 9-30

4. Chemokine Receptors: A Structural Overview

   • Gerard J. Graham, Robert J. Nibbs

   Pages 31-54

5. Chemokine Signaling in T-Lymphocyte Migration: The Role of Phosphoinositide 3-kinase

   • Laura Smith, Adam Webb, Stephen G. Ward

   Pages 55-70

6. Chemokine Receptors and Neutrophil Trafficking

   • Teizo Yoshimura

   Pages 71-86

7. Chemokine Receptors and Dendritic Cell Trafficking

   • Hiroyuki Yoneyama, Kenjiro Matsuno, Kouji Matsushima

   Pages 87-99

8. Chemokine Receptors and Lymphocyte Trafficking

   • Michael N. Hedrick, Joshua M. Farber

   Pages 101-118

9. Chemokines in Trafficking of Hematopoietic Stem and Progenitor Cells and Hematopoiesis

   • Chang H. Kim

   Pages 119-138

10. Chemokines in Transplantation Biology

    • Peter Jon Nelson, Stephan Segerer, Detlef Schlondorff

    Pages 139-154

11. The Chemokine System and Arthritis

    • Marlon P. Quinones, Fabio Jimenez, Carlos A. Estrada, Hernan G. Martiniez, Seema S. Ahuja

    Pages 155-198

12. Chemokine Receptors in Atherosclerosis

    • Maya R. Jerath, Mildred Kwan, Peng Liu, Dhavalkumar D. Patel

    Pages 199-233

13. Chemokine Receptors in Allergic Lung Disease

    • Dennis M. Lindell, Nicholas W. Lukacs

    Pages 235-257

14. Chemokine Receptors and HIV/AIDS

    • Tzanko S. Stantchev, Christopher C. Broder

    Pages 259-293

15. Chemokines and Their Receptors in Fibrosis

    • Glenda Trujillo, Cory M. Hogaboam

    Pages 295-317

16. Chemokines and Angiogenesis

    • Michael P. Keane, John A. Belperio, Robert M. Strieter

    Pages 319-333

17. Chemokine Receptors in Cancer: Pathobiology and Potential Therapeutic Targets

    • Tonya C. Walser, Amy M. Fulton

    Pages 335-349

18. Chemokine Receptors in Neuroinflammation

    • Astrid E. Cardona, Richard M. Ransohoff

    Pages 351-369

19. Pharmaceutical Targeting of Chemokine Receptors

    • Sofia Ribeiro, Richard Horuk

    Pages 371-390

20. Back Matter

    Pages 391-403

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G-protein coupled receptors (GPCRs) constitute a large superfamily of proteins that have been historically well represented as drug targets. As such, many of the volumes within The Receptors series have focused their attention on rec- tor subfamilies in the GPCR superfamily (e. g. , adrenergic, serotonergic, do- minergic). While chemokine receptors are relatively young, in terms of the knowledge that has accumulated regarding their roles in physiology and pat- logy, it is clear that this GPCR subfamily is dwar? ng all others with respect to the total number of receptors and their functional diversity. The breadth of the chemokine ? eld was not fully appreciated in the early days of chemokine d- covery, when the characterization of these molecules was largely a curiosity of a small set of biologists primarily interested in in? ammation. Presently, the ? eld of chemokinology is quite diverse, and it is nearly impossible to stay informed on all aspects of chemokine biology. Nonetheless, this book seeks to distill information regarding the molecular and cell biology, physiology, and pathology of chemokines and their receptors into a single volume, providing an excellent resource for those entering the ? eld or the most experienced c- mokinologist seeking new insights. In the chapters, leading authorities consider structural and cellular aspects of chemokines and chemokine receptors, and more notably, discuss the roles of these molecules in a variety of disease states that transcend their classically de? ned role(s) in in? ammation.

• AIDS
• Chemokine
• HIV
• cellular mechanisms
• infectious disease
• migration
• transplantation

From the reviews:

"This book aims to report the knowledge concerning chemokines and their receptors in the context of human physiology, pathology, and future therapeutic possibilities. … this book gives an interesting analysis of the different fields of knowledge and research concerning chemokines and their receptors in recent years. In this way, this book remains interesting for less experienced and mature researchers … ." (Liliane Gattegno, ChemMedChem, Issue 3, 2008)

"The Chemokine Receptors is an impressive and timely overview of the current knowledge in this field. The target readership includes researchers … clinicians including infectiologists, rheumatologists, oncologists and others may surely find information in this book, shedding light on their field of medicine. As such, the book can be used both by people entering the field and by more experienced researchers seeking new insights. … The volume contains numerous figures (including colour plates) as well as informative tables."(F. De Keyser, Acta Clinica Belgica, Vol. 63 (4), 2008)

• Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville

  Jeffrey K. Harrison

• Department of Pathology and Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor

  Nicholas W. Lukacs

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