Cell Therapy, Stem Cells and Brain Repair

1. Front Matter

   Pages i-xvi

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2. Current Views of the Embryonic and Neural Stem Cell

   • Roya Sabetrasekh, Yang D. Teng, Jitka Ourednik, Kook In Park, Evan Y. Snyder

   Pages 1-30

3. Developing Novel Cell Sources for Transplantation in Parkinson’s Disease

   • Nicolaj S. Christophersen, Ana Sofia Correia, Laurent Roybon, Jia-Yi Li, Patrik Brundin

   Pages 31-60

4. Neural Transplantation in the Nonhuman Primate Model of Parkinson’s Disease

   • Kimberly B. Bjugstad, John R. Sladek Jr.

   Pages 61-82

5. Cell-Based Therapy for Huntington’s Disease

   • Claire M. Kelly, Stephen B. Dunnett, Anne E. Rosser

   Pages 83-116

6. Use of Bone Marrow Stem Cells as Therapy for Behavioral Deficits in Rodent Models of Huntington’s Disease

   • Gary L. Dunbar, Justin D. Oh-Lee, Laurent Lescaudron

   Pages 117-138

7. Human Neuroteratocarcinoma Cells as a Neural Progenitor Graft Source for Cell Transplantation in Stroke

   • Cesario V. Borlongan, Christina Fournier, David C. Hess, Paul R. Sanberg

   Pages 139-162

8. Therapeutic Applications of Bone Marrow-Derived Stem Cells in Neurologic Injury and Disease

   • C.Dirk Keene, Xilma R. Ortiz-Gonzalez, Yuehua Jiang, Catherine M. Verfaillie, Walter C. Low

   Pages 163-197

9. Cell Therapy for Models of Pain and Traumatic Brain Injury

   • Mary Eaton, Jacqueline Sagen

   Pages 199-239

10. The Use of Sertoli Cells in Neural Transplantation

    • Dwaine F. Emerich, Cesario V. Borlongan, Craig R. Halberstadt

    Pages 241-259

11. The Choroid Plexus

    • Cesario V. Borlongan, Stephen J. M. Skinner, Alfred Vasconcellos, Robert B. Elliott, Dwaine F. Emerich

    Pages 261-285

12. Progress and Challenges in Immunoisolation for CNS Cell Therapy

    • Christopher G. Thanos, Dwaine F. Emerich

    Pages 287-323

13. Evidence-Based Methodology for Advancing Neural Reconstruction

    • Stephen Polgar

    Pages 325-339

14. Hematopoietic Cell Therapy for Brain Repair

    • Martina Vendrame, Alison E. Willing

    Pages 341-362

15. Stem Cells and Regenerative Medicine

    • L. Eduardo Cruz, Silvia P. Azevedo

    Pages 363-383

16. Back Matter

    Pages 385-391

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As our world continues to evolve, the field of regenerative medicine f- lows suit. Although many modern day therapies focus on synthetic and na- ral medicinal treatments for brain repair, many of these treatments and prescriptions lack adequate results or only have the ability to slow the p- gression of neurological disease or injury. Cell therapy, however, remains the most compelling treatment for neurodegenerative diseases, disorders, and injuries, including Parkinson’s disease, Huntington’s disease, traumatic brain injury, and stroke, which is expanded upon in more detail in Chapter 1 by Snyder and colleagues. Cell therapy is also unique in that it is the only therapeutic strategy that strives to replace lost, damaged, or dysfunctional cells with healthy ones. This repair and replacement may be due to an administration of exogenous cells itself or the activation of the body’s own endogenous reparative cells by a trophic, immune, or inflammatory response to cell transplantation. However, the precise mechanism of how cell therapy works remains elusive and is c- tinuing to be investigated in terms of molecular and cellular responses, in particular. Moreover, Chapter 11 by Emerich and associates, discusses some of the possibilities of cell immunoisolation and the potential for treating central nervous system diseases.

• Activation
• Nervous System
• Parkinson
• clinical application
• inflammatory response

"...covers the wide field of cell therapy and evaluates potential future treatments for neurodegenerative diseases and brain injuries...suitable for scientists and clinicians to gain a comprehensive overview on modern stem-cell research in regenerative medicine." -Schwfizer Archiv fur Neruologie und Psychiatrie

• Saneron CCEL Therapeutics, Tampa

  Cyndy Davis Sanberg

• University of South Florida College of Medicine, Tampa

  Paul R. Sanberg

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