Skip to main content
SpringerLink
Log in
Book cover

The G Protein-Coupled Receptors Handbook

  • Book
  • © 2005

Overview

Editors:
  1. Lakshmi A. Devi

    1. Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Contemporary Clinical Neuroscience (CCNE)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (18 chapters)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. GPCRs: Structure and Function

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Structure—Function Relationships in G Protein-Coupled Receptors

      • Dominique Massotte, Brigitte L. Kieffer
      Pages 3-31

    3. Molecular Mechanisms Involved in the Activation of Rhodopsin-Like Seven-Transmembrane Receptors

      • Peng Huang, Lee-Yuan Liu-Chen
      Pages 33-70

    4. GPCR Folding and Maturation

      • Ulla E. Petäjä-Repo, Michel Bouvier
      Pages 71-93

    5. Regulated Membrane Trafficking and Proteolysis of GPCRs

      • James N. Hislop, Mark von Zastrow
      Pages 95-105

  3. GPCR Activity and Its Regulators

    1. Front Matter

      Pages 107-107
      Download chapter PDF

    2. Heterotrimeric G Proteins and Their Effector Pathways

      • Tracy Nguyen Hwangpo, Ravi Iyengar
      Pages 109-134

    3. RGS Proteins

      • Ryan W. Richman, María A. Diversé-Pierluissi
      Pages 135-148

    4. G Protein-Coupled Receptor Kinases

      • Lan Ma, Jingxia Gao, Xiaoqing Chen
      Pages 149-158

    5. Regulators of GPCR Activity

      • Louis M. Luttrell
      Pages 159-198

    6. GPCR Interacting Proteins

      • Hongyan Wang, Catherine B. Willmore, Jia Bei Wang
      Pages 199-213

  4. GPCR Dimerization/Oligomerization

    1. Front Matter

      Pages 215-215
      Download chapter PDF

    2. Biophysical and Biochemical Methods to Study GPCR Oligomerization

      • Karen M. Kroeger, Kevin D. G. Pfleger, Karin A. Eidne
      Pages 217-241

    3. Oligomerization Domains of G Protein-Coupled Receptors

      • Marta Filizola, Wen Guo, Jonathan A. Javitch, Harel Weinstein
      Pages 243-265

    4. Functional Complementation and the Analysis of GPCR Dimerization

      • Graeme Milligan, Juan J. Carrillo, Geraldine Pascal
      Pages 267-285

    5. The Role of Oligomerization in G Protein-Coupled Receptor Maturation

      • Michael M. C. Kong, Christopher H. So, Brian F. O’Dowd, Susan R. George
      Pages 287-307

    6. Receptor Oligomerization and Trafficking

      • Selena E. Bartlett, Jennifer L. Whistler
      Pages 309-322

    7. Modulation of Receptor Pharmacology by G Protein-Coupled Receptor Dimerization

      • Noura S. Abul-Husn, Achla Gupta, Lakshmi A. Devi, Ivone Gomes
      Pages 323-346

  5. Recent Developments in Drug Discovery

    1. Front Matter

      Pages 347-347
      Download chapter PDF
Back to top

Keywords

About this book

A comprehensive survey of the many recent advances in the field of G protein-coupled receptors (GPCR). The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They also present new findings about how GPCR dimerization/oligomerization modifies the properties of individual receptors and show how recent developments are leading to significant advances in drug discovery, such as the detection of ligands for orphan GPCRs. Also discussed are the most recent developments that could lead to new drug discoveries: the role of GPCRs in mediating pain, the development of receptor-type selective drugs based on the structural plasticity of receptor activation, and the identification of natural ligands of orphan GPCRs (deorphanization) as possible drug targets.

Reviews

"...provides an excellent resource to introduce the reader to many of the diverse areas and questions that drive research in the GCPR field." -TRENDS in Endocrinology and Metablosim

Editors and Affiliations

  • Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York

    Lakshmi A. Devi

Bibliographic Information

  • Book Title: The G Protein-Coupled Receptors Handbook

  • Editors: Lakshmi A. Devi

  • Series Title: Contemporary Clinical Neuroscience

  • DOI: https://doi.org/10.1007/978-1-59259-919-6

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Humana Press 2005

  • Hardcover ISBN: 978-1-58829-365-7Published: 01 May 2005

  • Softcover ISBN: 978-1-61737-522-4Published: 01 December 2010

  • eBook ISBN: 978-1-59259-919-6Published: 01 March 2008

  • Series ISSN: 2627-535X

  • Series E-ISSN: 2627-5341

  • Edition Number: 1

  • Number of Pages: XVI, 412

  • Number of Illustrations: 47 b/w illustrations, 9 illustrations in colour

  • Topics: Neurosciences

Publish with us

Policies and ethics

Back to top

Search

Navigation